Evidence map›Paper›PMID 23375143›Full record

ArticleFertility and sterility2013

Assisted reproductive technologies and perinatal morbidity: interrogating the association.

Kurt T Barnhart

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Fertility and sterility, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 2 syntheses or guidelines pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author.

Kurt T BarnhartDepartment of Obstetrics and Gynecology, University of Pennsylvania, Philadelphia, Pennsylvania, USA. kbarnhart@obgyn.upenn.edu

Funding

Midcareer investigator award in patient oriented researchK24HD060687 · NICHD · UNIVERSITY OF PENNSYLVANIA · PI BARNHART, KURT T · 2009 to 2014
$956k
NICHD NIH HHS K24 HD060687NICHD NIH HHS K24HD060687
6 · The paper itself

Abstract

Interrogating the association between assisted reproductive technologies (ART) and perinatal outcome is complicated but very important. This is an introduction to a series of articles that review this potential association with an eye toward etiology of risk, and what aspects of in vitro fertilization (IVF) can be modified to reduce this risk. When an association is not due to chance (i.e., statistically significant), one must also consider how the association may be affected due to bias or confounding. Despite lack of the perfect study, perinatal consequences of ART are apparent, even though the vast majority of children conceived with ART are healthy. Pregnancy after IVF is altered as evidenced by risk of preterm delivery, low birth weight among infants, and an alerted prevalence of preeclampsia. The long-term clinical implications of ART, such as childhood development and metabolism, have not been established and ongoing study is proceeding. The risk attributed to multiple births is iatrogenic and needs to be minimized. Optimizing the environment at the time a woman conceives will likely have an effect on gestation as well as the health of children. Reproduction effects health and health effects reproduction.

Indexed as

CausalityComorbidityCongenital AbnormalitiesEvidence-Based MedicineFemaleHumansInfant, NewbornInfant, Newborn, DiseasesMalePregnancyPregnancy ComplicationsReproductive Techniques, AssistedRisk FactorsTreatment Outcome

Identifiers

PMID23375143
PMCPMC3564059

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.