ReviewCritical care (London, England)2013
Does artificial nutrition improve outcome of critical illness?
Review in Critical care (London, England), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. It is linked to trial NCT04242966 (The Effect of Higher Protein Dosing in Critically Ill Patients), which is not on this map. Cited by 15 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Effect of Higher Protein Dosing in Critically Ill Patients: A Multicenter Registry-based Randomized Trial: The EFFORT Ultrasound a Sub-study
Who cites it
15 citing papers in PubMed, 2 syntheses or guidelines pooled it, 80 citations in OpenAlex.
- Enteral versus parenteral nutrition and enteral versus a combination of enteral and parenteral nutrition for adults in the intensive care unit.The Cochrane database of systematic reviews · 2018Pooled it
- Energy, Protein, Carbohydrate, and Lipid Intakes and Their Effects on Morbidity and Mortality in Critically Ill Adult Patients: A Systematic Review.Advances in nutrition (Bethesda, Md.) · 2017Pooled it
- Calorie intake and patient outcomes in severe acute kidney injury: findings from The Randomized Evaluation of Normal vs. Augmented Level of Replacement Therapy (RENAL) study trial.Critical care (London, England) · 2014Trial
- Inflammation and Nutrition: Friend or Foe?Nutrients · 2023Review
- Toward nutrition improving outcome of critically ill patients: How to interpret recent feeding RCTs?Critical care (London, England) · 2023Review
- Mitochondrial Dysfunction in Critical Illness: Implications for Nutritional Therapy.Current nutrition reports · 2019Review
- Nutritional Management of Medical Inpatients.Journal of clinical medicine · 2019Review
- Effect of Calories Delivered on Clinical Outcomes in Critically Ill Patients: Systemic Review and Meta-analysis.Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine · 2017Article
- Editorial on the original article entitled "Permissive underfeeding of standard enteral feeding in critically ill adults" published in the New England Journal of Medicine on June 18, 2015.Annals of translational medicine · 2015Article
- Metabolic and nutritional support of critically ill patients: consensus and controversies.Critical care (London, England) · 2015Review
- Anorexia.Evolution, medicine, and public health · 2014Article
- The Effect of Nutritional Status in the Pathogenesis of Critical Illness Myopathy (CIM).Biology · 2014Article
- The nutritional energy to clinical outcome relation revisited.Critical care (London, England) · 2014Article
- Timing of (supplemental) parenteral nutrition in critically ill patients: a systematic review.Annals of intensive care · 2014Review
- Does artificial nutrition improve outcome of critical illness? An alternative viewpoint!Critical care (London, England) · 2013Review
Corrections and comments
- Erratum issued
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Nutritional support is generally considered an essential component in the management of critically ill patients. The existing guidelines advocate early enteral nutrition, with the optimal timing for the addition of parenteral nutrition to insufficient enteral feeding being the subject of transatlantic controversy. The unphysiologic intervention of artificial nutrition in critically ill patients, however, may evoke complications and side effects. Besides the classically described complications, suppression of autophagy, potentially important for cellular repair and organ recovery, was elucidated only recently. The question whether artificial nutrition in critical illness improves or worsens outcome as compared with starvation has so far not been adequately addressed. This paper provides a critical analysis of the existing literature on ICU nutrition, highlighting important methodological shortcomings of many trials and meta-analyses and underlining the urgent need for high-quality research in this field. Recent adequately designed randomized controlled trials suggest that trophic enteral feeding during the first week of critical illness is as good as full enteral feeding and that early addition of parenteral nutrition to insufficient enteral nutrition does not provide any benefit and worsens morbidity.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.