Trial reportInternational wound journal2014
Clinical efficacy of a silver-releasing foam dressing in venous leg ulcer healing: a randomised controlled trial.
Trial report in International wound journal, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed, 4 syntheses or guidelines pooled it, 28 citations in OpenAlex.
- Analysis of therapeutic effect of silver-based dressings on chronic wound healing.International wound journal · 2024Pooled it
- Silver dressings for the healing of venous leg ulcer: A meta-analysis and systematic review.Medicine · 2020Pooled it
- Dressings and topical agents for treating venous leg ulcers.The Cochrane database of systematic reviews · 2018Pooled it
- The use of biatain Ag in hard-to-heal venous leg ulcers: meta-analysis of randomised controlled trials.PloS one · 2013Pooled it
- Silver integrated hybrids and nanocomposites for next-generation biomedicine: Beyond antimicrobial coatings toward smart sense-response-heal platforms.Materials today. Bio · 2025Review
- Commercial Silver-Based Dressings: In Vitro and Clinical Studies in Treatment of Chronic and Burn Wounds.Antibiotics (Basel, Switzerland) · 2024Review
- Metal Nanoparticles: Advanced and Promising Technology in Diabetic Wound Therapy.International journal of nanomedicine · 2024Review
- Review
- Wound dressings: curbing inflammation in chronic wound healing.Emerging topics in life sciences · 2021Review
- The Effects of Silver-Releasing Foam Dressings on Diabetic Foot Ulcer Healing.Journal of clinical medicine · 2021Article
- Cost-effective use of silver dressings for the treatment of hard-to-heal chronic venous leg ulcers.PloS one · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Biatain and Biatain-Ag are two identical wound dressings except the fact that Biatain-Ag releases silver. In the present multinational double-blinded randomised controlled trial the effect of the two dressings were compared for treatment of venous leg ulcers. A total of 181 patients were treated for 6 weeks with either Biatain or Biatain-Ag followed by 4 weeks treatment with Biatain. Biatain-Ag showed superior performance in relative wound area reduction after 6 weeks treatment and the estimated treatment difference increased after 10 weeks indicating that the effect of silver continues at least for 4 weeks after treatment. A subgroup of the patients differed significantly from the others with respect to parameters associated with a poor healing prognosis; patients were older, had significant history of venous thrombosis, larger ulcers with longer duration and more often recurrent. For this subgroup of patients Biatain-Ag showed significant (P < 0·05) better performance in terms of relative ulcer area reduction and healing rate. In conclusion, this study suggests the superior performance of Biatain-Ag compared with the non silver-releasing dressing Biatain in particular for patients having ulcers associated with a poor healing prognosis.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.