Evidence map›Paper›PMID 23374455›Full record

ArticleJournal of the International Society of Sports Nutrition2013

International Society of Sports Nutrition Position Stand: beta-hydroxy-beta-methylbutyrate (HMB).

Jacob M Wilson, Peter J Fitschen, Bill Campbell, Gabriel J Wilson, Nelo Zanchi, Lem Taylor, Colin Wilborn, Douglas S Kalman, Jeffrey R Stout, Jay R Hoffman and 5 more

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of the International Society of Sports Nutrition, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02773771 (Strategies to Reduce Organic Muscle Atrophy in the Intensive Care Unit), which is not on this map. Cited by 76 papers, 12 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
76citing papers in PubMed, 12 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02773771 phase2 / phase3withdrawnnot on this mapstarted 2017, after this paper: background citation

Strategies to Reduce Organic Muscle Atrophy in the Intensive Care Unit (STROMA-ICU)

TypeinterventionalSponsorMassachusetts General HospitalRan2017 to 2019Enrolled0ConditionsMuscle AtrophyArmsbeta-hydroxy-beta-methylbutyrate, Placebo, Vital HP®
3 · Its place in the literature

Who cites it

76 citing papers in PubMed, 12 syntheses or guidelines pooled it.

  1. Adjunctive Ashwagandha (Nutrients · 2026
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16 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Jacob M WilsonDepartment of Health Sciences and Human Performance, University of Tampa, Tampa, FL, USA.
Peter J FitschenDivision of Nutritional Sciences, University of Illinois, Urbana, IL, USA.
Bill Campbell *Exercise and Performance Nutrition Laboratory, Dept. of Physical Education and Exercise Science, University of South Florida, 4202 E. Fowler Avenue, PED 214, Tampa, FL, 33620, USA.
Gabriel J WilsonDepartment of Nutritional Sciences, Rutgers, The State University of New Jersey, New Brunswick, NJ, USA.
Nelo Zanchi *Laboratory of Applied Nutrition and Metabolism, Physical Education and School of Sports, University of São Paulo, São Paulo, Brazil.
Lem Taylor *Human Performance Laboratory, Exercise & Sport Science Department, University of Mary Hardin-Baylor, Belton, TX, 76513, USA.
Colin Wilborn *Human Performance Laboratory, Exercise & Sport Science Department, University of Mary Hardin-Baylor, Belton, TX, 76513, USA.
Douglas S KalmanMiami Research Associates, Endocrinology & Nutrition Department, 6141 Sunset Drive - Suite 301, Miami, FL, 33143, USA.
Jeffrey R StoutInstitute of Exercise Physiology and Wellness, University of Central Florida, Orlando, FL, 32816, USA.
Jay R HoffmanInstitute of Exercise Physiology and Wellness, University of Central Florida, Orlando, FL, 32816, USA.
Tim N ZiegenfussThe Center for Applied Health Sciences, Stow, OH, 44224, USA.
Hector L LopezThe Center for Applied Health Sciences, Stow, OH, 44224, USA.
Richard B KreiderExercise & Sport Nutrition Lab, Department of Health & Kinesiology, Texas A&M University, College Station, TX, USA.
Abbie E Smith-RyanApplied Physiology Laboratory, Department of Exercise and Sport Science, University of North Carolina Chapel Hill, Chapel Hill, NC, 27599-8605, USA.
Jose Antonio *Exercise and Sports Science, Nova Southeastern University, Davie, FL, 33314, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Position Statement: The International Society of Sports Nutrition (ISSN) bases the following position stand on a critical analysis of the literature on the use of beta-hydroxy-beta-methylbutyrate (HMB) as a nutritional supplement. The ISSN has concluded the following. 1. HMB can be used to enhance recovery by attenuating exercise induced skeletal muscle damage in trained and untrained populations. 2. If consuming HMB, an athlete will benefit from consuming the supplement in close proximity to their workout. 3. HMB appears to be most effective when consumed for 2 weeks prior to an exercise bout. 4. Thirty-eight mg·kg·BM-1 daily of HMB has been demonstrated to enhance skeletal muscle hypertrophy, strength, and power in untrained and trained populations when the appropriate exercise prescription is utilized. 5. Currently, two forms of HMB have been used: Calcium HMB (HMB-Ca) and a free acid form of HMB (HMB-FA). HMB-FA may increase plasma absorption and retention of HMB to a greater extent than HMB-CA. However, research with HMB-FA is in its infancy, and there is not enough research to support whether one form is superior. 6. HMB has been demonstrated to increase LBM and functionality in elderly, sedentary populations. 7. HMB ingestion in conjunction with a structured exercise program may result in greater declines in fat mass (FM). 8. HMB's mechanisms of action include an inhibition and increase of proteolysis and protein synthesis, respectively. 9. Chronic consumption of HMB is safe in both young and old populations.

Identifiers

PMID23374455
PMCPMC3568064

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.