ArticleCell2013
GWAS meets TCGA to illuminate mechanisms of cancer predisposition.
Article in Cell, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed.
- A Bayesian Model for Paired Data in Genome-Wide Association Studies with Application to Breast Cancer.Entropy (Basel, Switzerland) · 2025Article
- Leveraging Random Effects in Cistrome-Wide Association Studies for Decoding the Genetic Determinants of Prostate Cancer.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Inconsistency in the expression pattern of a five-lncRNA signature as a potential diagnostic biomarker for gastric cancer patients in bioinformatics andIranian journal of basic medical sciences · 2022Article
- LncRNA PCAT19 induced by SP1 and acted as oncogene in gastric cancer competitively binding to miR429 and upregulating DHX9.Journal of Cancer · 2022Article
- Cutaneous Melanoma - A Review of Systemic Therapies.Acta dermato-venereologica · 2020Review
- Candidate genes for predicting the survival of patients with gastric cancer: a study based on The Cancer Genome Atlas (TCGA) database.Translational cancer research · 2020Article
- Germline Features Associated with Immune Infiltration in Solid Tumors.Cell reports · 2020Article
- Long non-coding RNA TGLC15 advances hepatocellular carcinoma by stabilizing Sox4.Journal of clinical laboratory analysis · 2020Article
- Screening of a Novel Upregulated lncRNA, A2M-AS1, That Promotes Invasion and Migration and Signifies Poor Prognosis in Breast Cancer.BioMed research international · 2020Article
- Targeting Oncogenic BRAF: Past, Present, and Future.Cancers · 2019Review
- Genome-wide analysis of long non-coding RNAs in esophageal squamous cell carcinoma reveals their potential role in invasion and metastasis.Thoracic cancer · 2019Article
- Overexpressed long noncoding RNAOncoTargets and therapy · 2019Article
- Long Stress Induced Non-Coding Transcripts 5 (LSINCT5) Promotes Hepatocellular Carcinoma Progression Through Interaction with High-Mobility Group AT-hook 2 and MiR-4516.Medical science monitor : international medical journal of experimental and clinical research · 2018Article
- The MALAT1 gene polymorphism and its relationship with the onset of congenital heart disease in Chinese.Bioscience reports · 2018Article
- MicroRNA-148a deficiency promotes hepatic lipid metabolism and hepatocarcinogenesis in mice.Cell death & disease · 2017Article
- HOTAIR rs7958904 polymorphism is associated with increased cervical cancer risk in a Chinese population.Scientific reports · 2017Article
- Biomarkers of genome instability and cancer epigenetics.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2016Review
- microRNA-206 impairs c-Myc-driven cancer in a synthetic lethal manner by directly inhibiting MAP3K13.Oncotarget · 2016Article
- Review
- Functional annotation of HOT regions in the human genome: implications for human disease and cancer.Scientific reports · 2015Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Genome-wide association studies (GWASs) have unraveled a large number of cancer risk alleles. Understanding how these allelic variants predispose to disease is a major bottleneck confronting translational application. In this issue, Li and colleagues combine GWASs with The Cancer Genome Atlas (TCGA) to disambiguate the contributions of germline and somatic variants to tumorigenic gene expression programs. They find that close to half of the known risk alleles for estrogen receptor (ER)-positive breast cancer are expression quantitative trait loci (eQTLs) acting upon major determinants of gene expression in tumors.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.