ArticleCell2013
Conformational ensembles in GPCR activation.
Article in Cell, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed.
- Agonism and Biased Signaling.Handbook of experimental pharmacology · 2026Review
- Principles and Design of Molecular Tools for Sensing and Perturbing Cell Surface Receptor Activity.Chemical reviews · 2025Review
- Mechanistic basis of GPCR activation explored by ensemble refinement of crystallographic structures.Protein science : a publication of the Protein Society · 2022Article
- Essential Dynamics Ensemble Docking for Structure-Based GPCR Drug Discovery.Frontiers in molecular biosciences · 2022Article
- Structural Characterization of KOR Inactive and Active States for 3D Pharmacology and Drug Discovery.Handbook of experimental pharmacology · 2022Review
- A versatile GPCR toolkit to track in vivo neuromodulation: not a one-size-fits-all sensor.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2021Article
- Elucidation of Mechanism for Ligand Efficacy at Leukotriene BACS medicinal chemistry letters · 2020Article
- Multiscale design of coarse-grained elastic network-based potentials for the μ opioid receptor.Journal of molecular modeling · 2016Article
- New Technologies for Elucidating Opioid Receptor Function.Trends in pharmacological sciences · 2016Review
- DREADDs for Neuroscientists.Neuron · 2016Review
- Conformational Flexibility in the Transmembrane Protein TSPO.Chemistry (Weinheim an der Bergstrasse, Germany) · 2015Article
- SPECTRAL METHODS FOR STUDY OF THE G-PROTEIN-COUPLED RECEPTOR RHODOPSIN. I. VIBRATIONAL AND ELECTRONIC SPECTROSCOPY.Optics and spectroscopy · 2015Article
- Identification of novel functionally selective κ-opioid receptor scaffolds.Molecular pharmacology · 2014Article
- Chemotype-selective modes of action of κ-opioid receptor agonists.The Journal of biological chemistry · 2013Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Recent advances in G-protein-coupled receptor structural biology have provided only limited insight into the active conformations of these key signaling molecules. A paper from Nygaard et al. reveals the dynamic nature of GPCRs along the activation pathway by complementing NMR experiments with ultralong-timescale molecular dynamics simulations.
Identifiers
23374334What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.