Trial reportPsychoneuroendocrinology2013
The effects of exogenous progesterone on drug craving and stress arousal in cocaine dependence: impact of gender and cue type.
Trial report in Psychoneuroendocrinology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 65 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
65 citing papers in PubMed, 3 syntheses or guidelines pooled it, 144 citations in OpenAlex.
- The influence of sex and reproductive cycle on cocaine-induced behavioral and neurobiological alterations: a review.Experimental brain research · 2022Pooled it
- Sex Differences in Opioid and Psychostimulant Craving and Relapse: A Critical Review.Pharmacological reviews · 2022Pooled it
- The effect of laboratory manipulations of negative affect on alcohol craving and use: A meta-analysis.Psychology of addictive behaviors : journal of the Society of Psychologists in Addictive Behaviors · 2018Pooled it
- Effect of conditioned stimuli-triggered memory retrieval-extinction in patients with methamphetamine use disorder.Translational psychiatry · 2025Trial
- The effect of oxytocin, gender, and ovarian hormones on stress reactivity in individuals with cocaine use disorder.Psychopharmacology · 2020Trial
- Exogenous progesterone for cannabis withdrawal in women: Feasibility trial of a novel multimodal methodology.Pharmacology, biochemistry, and behavior · 2019Trial
- Neuroactive steroid levels and cocaine use chronicity in men and women with cocaine use disorder receiving progesterone or placebo.The American journal on addictions · 2019Trial
- Impact of endogenous progesterone on reactivity to yohimbine and cocaine cues in cocaine-dependent women.Pharmacology, biochemistry, and behavior · 2018Trial
- Effects of progesterone stimulated allopregnanolone on craving and stress response in cocaine dependent men and women.Psychoneuroendocrinology · 2016Trial
- Progesterone Attenuates the Stress Response in Individuals with Alcohol Dependence and Post-Traumatic Stress Disorder - A Pilot Study.Journal of dual diagnosisTrial
- Sex differences in stress responding in a randomized, placebo-controlled clinical trial of progesterone in cannabis use disorder.Psychopharmacology · 2026Article
- Cocaine Cues Used in Experimental Research: A Systematic Review.Brain sciences · 2025Review
- Oxytocin Attenuates the Endocrine Disrupting Effects of Cocaine in the Female Rat.Endocrinology · 2025Article
- Sex differences in stress-modulated cocaine vulnerability: female rodents are more sensitive to the effects of stress exposure at different developmental stages.Frontiers in behavioral neuroscience · 2025Review
- Laboratory and Real-World Experimental Approaches to Understanding Alcohol Relapse.Current topics in behavioral neurosciences · 2025Review
- Stress and substance use disorders: risk, relapse, and treatment outcomes.The Journal of clinical investigation · 2024Review
- Biological sex and hormonal contraceptive associations with drug cue reactivity in cannabis use disorder.Journal of psychiatric research · 2024Article
- Neuroactive Steroids, Toll-like Receptors, and Neuroimmune Regulation: Insights into Their Impact on Neuropsychiatric Disorders.Life (Basel, Switzerland) · 2024Review
- The role of neurosteroids in posttraumatic stress disorder and alcohol use disorder: A review of 10 years of clinical literature and treatment implications.Frontiers in neuroendocrinology · 2024Review
- Sex differences in glutamate transmission and plasticity in reward related regions.Frontiers in behavioral neuroscience · 2024Review
5 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
aimsExogenous progesterone has been shown to attenuate the rewarding effects of cocaine. However, its effects on provoked drug craving, stress arousal and cognitive performance has not been systematically investigated in cocaine dependent men and women. Thus, we conducted a double-blind placebo-controlled study assessing the efficacy of progesterone in reducing provoked drug craving, stress system arousal and improving cognitive performance in cocaine dependent men and women.
methodsForty-two early abstinent treatment-seeking cocaine dependent individuals were randomly assigned to either daily doses of placebo (12M/9F) or micronized progesterone (12M/9F) (400 mg/day), for 7 days. Under experimental conditions, all subjects were exposed to three 5-min personalized guided imagery conditions (stress, cocaine cue, relaxing), one per day, consecutively in a random, counterbalanced order. Subjective craving, mood, hypothalamic-pituitary-adrenal (HPA) and cardiovascular output, and a cognitive measure of inhibitory control (Stroop Color Word Task) were assessed pre- and post imagery.
resultsProgesterone relative to placebo significantly decreased cue-induced craving and cortisol responses and increased cue-induced ACTH. In addition, women but not men receiving progesterone reported lower ratings of negative emotion and higher ratings of relaxed mood following stress exposure. Improved Stroop performance was observed in all participants receiving progesterone, across all conditions.
conclusionsProgesterone was selectively effective in reducing cocaine cue-induced but not stress-related cocaine craving as well as specific measures of the provoked arousal state. Findings suggest that progesterone's effects on drug craving and arousal are moderated by both the type of environmental cue exposure and gender.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.