ArticleBiology of sex differences2013
Hormonal modulation of connective tissue homeostasis and sex differences in risk for osteoarthritis of the knee.
Article in Biology of sex differences, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
42 citing papers in PubMed, 3 syntheses or guidelines pooled it, 58 citations in OpenAlex.
- Prevalence of knee osteoarthritis in the Chinese population, 2013-2023: a systematic review and meta-analysis.Journal of orthopaedic surgery and research · 2025Pooled it
- Exploring In Vivo Models of Musculoskeletal Frailty: A Comprehensive Systematic Review.International journal of molecular sciences · 2023Pooled it
- Sex Specific Determinants in Osteoarthritis: A Systematic Review of Preclinical Studies.International journal of molecular sciences · 2020Pooled it
- Reply to the Letter to the Editor: Cartilage T2 elevation in adolescent athletes-adaptation or early risk?European radiology · 2026Article
- Circulating matrix GLA protein during puberty in healthy and central precocious puberty children.Endocrine connections · 2026Article
- Article
- Sex differences in the pathogenesis of degenerative knee osteoarthritis: a comparative transcriptomics analysis.Frontiers in aging · 2026Article
- TheGenes · 2025Observational
- Effect of Androgens on Human Fascia.Biology · 2025Article
- Low-Grade Inflammatory Mediators and Metalloproteinases Yield Synchronous and Delayed Responses to Mechanical Joint Loading.Cartilage · 2024Article
- Unraveling the complex interplay of sex, endocrinology, and inflammation in post-Injury articular cartilage breakdown through in silico modeling.Scientific reports · 2024Article
- Prevalence of MTHFR Polymorphisms in Patients With Hypermobile Ehlers-Danlos Syndrome and Hypermobile Spectrum Disorders in a US Hypermobility Clinic.ACR open rheumatology · 2024Article
- A missed opportunity: A scoping review of the effect of sex and age on osteoarthritis using large animal models.Osteoarthritis and cartilage · 2024Article
- Article
- The Metabolic Syndrome, a Human Disease.International journal of molecular sciences · 2024Review
- Reasons for the Sex Bias in Osteoarthritis Research: A Review of Preclinical Studies.International journal of molecular sciences · 2023Review
- Correlation between the Signal Intensity Alteration of Infrapatellar Fat Pad and Knee Osteoarthritis: A Retrospective, Cross-Sectional Study.Journal of clinical medicine · 2023Article
- Transcriptomic response of bioengineered human cartilage to parabolic flight microgravity is sex-dependent.NPJ microgravity · 2023Article
- Osteoarthritis as an Umbrella Term for Different Subsets of Humans Undergoing Joint Degeneration: The Need to Address the Differences to Develop Effective Conservative Treatments and Prevention Strategies.International journal of molecular sciences · 2022Review
- Mass spectrometry-based proteomics identify novel serum osteoarthritis biomarkers.Arthritis research & therapy · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Young female athletes experience a higher incidence of ligament injuries than their male counterparts, females experience a higher incidence of joint hypermobility syndrome (a risk factor for osteoarthritis development), and post-menopausal females experience a higher prevalence of osteoarthritis than age-matched males. These observations indicate that fluctuating sex hormone levels in young females and loss of ovarian sex hormone production due to menopause likely contribute to observed sex differences in knee joint function and risk for loss of function. In studies of osteoarthritis, however, there is a general lack of appreciation for the heterogeneity of hormonal control in both women and men. Progress in this field is limited by the relatively few preclinical osteoarthritis models, and that most of the work with established models uses only male animals. To elucidate sex differences in osteoarthritis, it is important to examine sex hormone mechanisms in cells from knee tissues and the sexual dimorphism in the role of inflammation at the cell, tissue, and organ levels. There is a need to determine if the risk for loss of knee function and integrity in females is restricted to only the knee or if sex-specific changes in other tissues play a role. This paper discusses these gaps in knowledge and suggests remedies.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.