Evidence map›Paper›PMID 23374150›Full record

ArticleViral immunology2013

Peptide immunization elicits polyomavirus-specific MHC class ib-restricted CD8 T cells in MHC class ia allogeneic mice.

Amelia R Hofstetter, Brian D Evavold, Aron E Lukacher

Abstract read
In one paragraph

Article in Viral immunology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Amelia R HofstetterDepartment of Microbiology and Immunology, Emory University, Atlanta, GA, USA.
Brian D Evavold
Aron E Lukacher
Emory University · USPennsylvania State University · US

Funding

Analysis of MHC Class Ib-Restricted Polyoma Virus-Specific CD8 T CellsR01CA139220 · NCI · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI LUKACHER, ARON ELIOT · 2009 to 2013
$1.6M
NCI NIH HHS CA139220NCI NIH HHS R01 CA139220
6 · The paper itself

Abstract

Unlike the polymorphic MHC class Ia molecules, MHC class Ib molecules are oligomorphic or nonpolymorphic. We recently discovered a protective CD8 T cell response to mouse polyomavirus (MPyV) in H-2(b) haplotype mice that is restricted by H2-Q9, a member of the Qa-2 MHC class Ib family. Here, we demonstrate that immunization with a peptide corresponding to a virus capsid-derived peptide presented by Q9 also elicits MHC class Ib-restricted MPyV-specific CD8 T cells in mice of H-2(s) and H-2(g7) strains. These findings support the concept that immunization with a single MHC class Ib-restricted peptide can expand CD8 T cells in MHC class Ia allogeneic hosts.

Indexed as

AnimalsCapsid ProteinsCD8-Positive T-LymphocytesFemaleGenotypeH-2 AntigensMicePolyomavirusVaccines, SubunitCapsid ProteinsH-2 AntigensVaccines, Subunit

Identifiers

PMID23374150
PMCPMC3578367
OpenAlexW1993261938

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.