Trial reportPediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology2013
Associations of postnatal growth with asthma and atopy: the PROBIT Study.
Trial report in Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01561612 (Breastfeeding Promotion RCT and Child Metabolic Syndrome), which is not on this map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Breastfeeding Promotion RCT and Child Metabolic Syndrome
Who cites it
17 citing papers in PubMed, 29 citations in OpenAlex.
- Effects of Promoting Long-term, Exclusive Breastfeeding on Adolescent Adiposity, Blood Pressure, and Growth Trajectories: A Secondary Analysis of a Randomized Clinical Trial.JAMA pediatrics · 2017Trial
- Socioeconomic differences in childhood length/height trajectories in a middle-income country: a cohort study.BMC public health · 2014Trial
- Postnatal growth and childhood asthma in preterm and full-term twins: A cohort study.Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology · 2026Article
- Perinatal Characteristics and the Sensitization to Cow Milk, Egg Whites and Wheat in Children up to 3 Years of Age.Children (Basel, Switzerland) · 2023Article
- Early-life weight gain is associated with non-atopic asthma in childhood.The World Allergy Organization journal · 2022Article
- Association of pediatric obesity and asthma, pulmonary physiology, metabolic dysregulation, and atopy; and the role of weight management.Expert review of endocrinology & metabolism · 2019Review
- Infant Feeding, Vitamin D and IgE Sensitization to Food Allergens at 6 Years in a Longitudinal Icelandic Cohort.Nutrients · 2019Article
- Investigating the relationship between fetal growth and academic attainment: secondary analysis of the Born in Bradford (BiB) cohort.International journal of epidemiology · 2018Article
- Socioeconomic differences in childhood BMI trajectories in Belarus.International journal of obesity (2005) · 2018Article
- Effects of infant weight gain on subsequent allergic outcomes in the first 3 years of life.BMC pediatrics · 2017Article
- Associations between early body mass index trajectories and later metabolic risk factors in European children: the IDEFICS study.European journal of epidemiology · 2016Article
- Body mass index and physical activity in early childhood are associated with atopic sensitization, atopic dermatitis and asthma in later childhood.Clinical and translational allergy · 2016Article
- Effects of birth weight and growth on childhood wheezing disorders: findings from the Born in Bradford Cohort.BMJ open · 2015Observational
- Influence of childhood growth on asthma and lung function in adolescence.The Journal of allergy and clinical immunology · 2015Article
- Postnatal growth and the heterogeneity of preschool wheeze.The Journal of pediatrics · 2015Article
- Peak weight and height velocity to age 36 months and asthma development: the Norwegian Mother and Child Cohort Study.PloS one · 2015Article
- Modelling childhood growth using fractional polynomials and linear splines.Annals of nutrition & metabolism · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 3 institutions in 3 countries.
Funding
Abstract
backgroundIt has been hypothesised that postnatal weight and length/height gain are variously related to wheeze, asthma and atopy; however, supporting evidence is limited and inconsistent.
methodsWeights and lengths/heights of 12,171 term infants were measured from birth to 12 months and at 6.5 yr and extracted from polyclinic records prospectively obtained between 12 and 60 months. Atopic phenotypes were ascertained at 6.5 yr with the International Study of Asthma and Allergy in Childhood questionnaire and skin prick tests. Logistic regression models investigated whether rates of weight and length/height gain from infancy to mid-childhood were associated with atopy phenotypes that have occurred ever or in the last 12 months.
resultsAfter controlling for confounders and prior weight and length/height gain, all weight gain variables except birth weight were positively associated with ever having wheezed (p < 0.1). A one s.d. increase in weight gain rate between 0 and 3 months was associated with a 12% increase (2-23%) in allergic rhinitis ever. No other consistent patterns of association were found for weight gain or length/height gain rate between 0 and 60 months with atopic outcomes at 6.5 yr. In contrast, all atopy outcomes except for ever having asthma were associated with current weight and height, even after controlling for prior growth.
conclusionCurrent height and weight are more strongly associated with the development of atopic phenotypes in childhood than patterns of infant and early childhood growth, which may well reflect reverse causality (atopy effects on growth) or residual confounding by an unknown common cause of growth and atopy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.