ArticleThyroid : official journal of the American Thyroid Association2013
Remnant uptake as a postoperative oncologic quality indicator.
Article in Thyroid : official journal of the American Thyroid Association, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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17 citing papers in PubMed, 55 citations in OpenAlex.
- Comparison betweenQuantitative imaging in medicine and surgery · 2026Article
- Evaluation of Preoperative Factors as Predictors of Difficult Thyroidectomy: A Prospective Study.Cureus · 2025Article
- A digital pathology model for predicting radioiodine-avid metastases on initial post-therapeuticScientific reports · 2024Article
- Oldie but Goldie: The Fundamental Role of Radioiodine in the Management of Thyroid Cancer.Journal of clinical medicine · 2024Article
- Postoperative thyroglobulin as a yard-stick for radioiodine therapy: decision tree analysis in a European multicenter series of 1317 patients with differentiated thyroid cancer.European journal of nuclear medicine and molecular imaging · 2023Article
- Radioactive iodine therapy: multiple faces of the same polyhedron.Archives of endocrinology and metabolism · 2022Review
- Volume, outcomes, and quality standards in thyroid surgery: an evidence-based analysis-European Society of Endocrine Surgeons (ESES) positional statement.Langenbeck's archives of surgery · 2020Review
- Article
- Star-Shaped Intense Uptake of ¹³¹I on Whole Body Scans Can Reflect Good Therapeutic Effects of Low-Dose Radioactive Iodine Treatment of 1.1 GBq.Endocrinology and metabolism (Seoul, Korea) · 2018Article
- Thyroid Remnant Estimation by Diagnostic Dose (131)I Scintigraphy or (99m)TcO4(-) Scintigraphy after Thyroidectomy: A Comparison with Therapeutic Dose (131)I Imaging.BioMed research international · 2016Article
- Thyroglobulin antibody resolution after total thyroidectomy for cancer.The Journal of surgical research · 2015Article
- [Total thyroidectomy with lymph node dissection of the central compartment for node-positive, capsular invasive papillary thyroid cancer: video contribution].Der Chirurg; Zeitschrift fur alle Gebiete der operativen Medizen · 2014Article
- Novel thyroidectomy difficulty scale correlates with operative times.World journal of surgery · 2014Article
- Radioactive iodine remnant uptake after completion thyroidectomy: not such a complete cancer operation.Annals of surgical oncology · 2014Article
- Markedly elevated thyroglobulin levels in the preoperative thyroidectomy patient correlates with metastatic burden.The Journal of surgical research · 2014Article
- Relation between surgical oncologic quality indicators for papillary thyroid cancer.Canadian journal of surgery. Journal canadien de chirurgieArticle
- A Review of TENIS Syndrome in Hospital Pulau Pinang.Indian journal of nuclear medicine : IJNM : the official journal of the Society of Nuclear Medicine, IndiaArticle
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4 authors at 1 institution in 1 country.
Funding
Abstract
backgroundThe purpose of this study was to examine the utility of remnant uptake on postoperative radioiodine scans as an oncologic indicator after thyroidectomy for differentiated thyroid cancer (DTC).
methodsWe conducted a retrospective review of patients undergoing total thyroidectomy for DTC and subsequent radioactive iodine (RAI) treatment. Of the eight surgeons included, three were considered high volume, performing at least 20 thyroidectomies per year. Patients with distant metastases at diagnosis or poorly differentiated variants were excluded. To control for the effect of varying RAI doses, the remnant uptake was analyzed as a ratio of the percentage uptake to the dose received (uptake to dose ratio [UDR]). Multivariate logistic regression was used to determine the influence of UDR on recurrence.
resultsOf the 223 patients who met inclusion criteria, 21 patients (9.42%) experienced a recurrence. Those with a recurrence had a 10-fold higher UDR compared with those who did not (0.030 vs. 0.003, p=0.001). Similarly, patients with increasing postoperative thyroglobulin measurements (0.339 vs. 0.003, p<0.001) also had significantly greater UDRs compared with those with stable thyroglobulin. The UDRs of high-volume surgeons were significantly smaller than low-volume surgeons (0.003 vs. 0.025, p=0.002). When combined with other known predictors for recurrence, UDR (OR 3.71 [95%CI 1.05-13.10], p=0.041) was significantly associated with recurrence. High-volume surgeons maintained a low level of permanent complications across all UDRs, whereas low-volume surgeons had greater permanent complications associated with higher uptake.
conclusionsRemnant uptake is a useful postoperative oncologic quality indicator that can predict a patient's risk of disease recurrence and indicate the completeness of resection.
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