ArticlePulmonary circulation2012
In vivo and in vitro measurements of pulmonary arterial stiffness: A brief review.
Article in Pulmonary circulation, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
24 citing papers in PubMed, 37 citations in OpenAlex.
- Dataset for studying deformation in 3D patient-specific pulmonary artery anatomies.Scientific data · 2026Article
- Mitochondrial Targeting by Elamipretide Improves Myocardial Bioenergetics Without Translating into Functional Benefits in HFpEF.International journal of molecular sciences · 2026Article
- A Brief Overview of Biomechanics and Mechanobiology of the Pulmonary Circulation.Advances in experimental medicine and biology · 2026Review
- ZSF1 lean rats - How healthy are they?Animal models and experimental medicine · 2025Article
- Pharmacologic Management of Segmental Pulmonary Hypertension in Children After Unifocalization and Pulmonary Artery Reconstruction: Initial Experience.Pulmonary circulation · 2025Article
- Current Overview of the Biology and Pharmacology in Sugen/Hypoxia-Induced Pulmonary Hypertension in Rats.Journal of aerosol medicine and pulmonary drug delivery · 2024Review
- Mechanical and Structural Adaptation of the Pulmonary Root after Ross Operation in a Murine Model.Journal of clinical medicine · 2022Article
- Characterization of main pulmonary artery and valve annulus region of piglets using echocardiography, uniaxial tensile testing, and a novel non-destructive technique.Frontiers in cardiovascular medicine · 2022Article
- Inverse modeling framework for characterizing patient-specific microstructural changes in the pulmonary arteries.Journal of the mechanical behavior of biomedical materials · 2021Article
- The time has come to extend the expiration limit of cryopreserved allograft heart valves.Cell and tissue banking · 2021Review
- Exercise-Induced Changes in Pulmonary Artery Stiffness in Pulmonary Hypertension.Frontiers in physiology · 2019Article
- Letter to the Editor.Journal of veterinary internal medicine · 2016Article
- A Framework for Local Mechanical Characterization of Atherosclerotic Plaques: Combination of Ultrasound Displacement Imaging and Inverse Finite Element Analysis.Annals of biomedical engineering · 2016Article
- Validation of an arterial constitutive model accounting for collagen content and crosslinking.Acta biomaterialia · 2016Article
- The Critical Role of Pulmonary Arterial Compliance in Pulmonary Hypertension.Annals of the American Thoracic Society · 2016Review
- Stretch calculated from grip distance accurately approximates mid-specimen stretch in large elastic arteries in uniaxial tensile tests.Journal of the mechanical behavior of biomedical materials · 2015Article
- A novel in vivo approach to assess radial and axial distensibility of large and intermediate pulmonary artery branches.Journal of biomechanical engineering · 2015Article
- Effect of acute arteriolar vasodilation on capacitance and resistance in pulmonary arterial hypertension.Chest · 2015Article
- Vascular stiffening in pulmonary hypertension: cause or consequence? (2013 Grover Conference series).Pulmonary circulation · 2014Article
- Characterization of regional deformation and material properties of the intact explanted vein by microCT and computational analysis.Cardiovascular engineering and technology · 2014Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
During the progression of pulmonary hypertension (PH), proximal pulmonary arteries (PAs) undergo remodeling such that they become thicker and the elastic modulus increases. Both of these changes increase the vascular stiffness. The increase in pulmonary vascular stiffness contributes to increased right ventricular (RV) afterload, which causes RV hypertrophy and eventually failure. Studies have found that proximal PA stiffness or its inverse, compliance, is strongly related to morbidity and mortality in patients with PH. Therefore, accurate in vivo measurement of PA stiffness is useful for prognoses in patients with PH. It is also important to understand the structural changes in PAs that occur with PH that are responsible for stiffening. Here, we briefly review the most common parameters used to quantify stiffness and in vivo and in vitro methods for measuring PA stiffness in human and animal models. For in vivo approaches, we review invasive and noninvasive approaches that are based on measurements of pressure and inner or outer diameter or cross-sectional area. For in vitro techniques, we review several different testing methods that mimic one, two or several aspects of physiological loading (e.g., uniaxial and biaxial testing, dynamic inflation-force testing). Many in vivo and in vitro measurement methods exist in the literature, and it is important to carefully choose an appropriate method to measure PA stiffness accurately. Therefore, advantages and disadvantages of each approach are discussed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.