ArticlePloS one2013
Serum glucose and fructosamine in relation to risk of cancer.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 21 citations in OpenAlex.
- Serum glucose and risk of cancer: a meta-analysis.BMC cancer · 2014Pooled it
- Poor glycemic control is associated with reduced prostate specific antigen concentrations in men with type 1 diabetes.The Journal of urology · 2015Trial
- Metabolic and inflammatory biomarker trajectories after a cancer diagnosis and the risk of cardiovascular diseases.Nature communications · 2026Article
- Evaluation of Serum Fructosamine as Diagnostic Marker of Postoperative Recurrence in the Patients with Breast Cancer.BioMed research international · 2023Article
- Review
- Evaluation of Fructosamine 3-kinase and Glyoxalase 1 activity in normal and breast cancer tissues.BioMedicine · 2021Article
- Diabetes mellitus is independently associated with adverse clinical outcome in soft tissue sarcoma patients.Scientific reports · 2020Article
- Metabolic profiles to predict long-term cancer and mortality: the use of latent class analysis.BMC molecular and cell biology · 2019Article
- Hyperglycemia, Classified with Multiple Biomarkers Simultaneously in Men without Diabetes, and Risk of Fatal Prostate Cancer.Cancer prevention research (Philadelphia, Pa.) · 2019Article
- Hyperglycaemia is associated with cancer-related but not non-cancer-related deaths: evidence from the IPC cohort.Diabetologia · 2018Article
- Article
- Circulating gamma-glutamyl transferase and development of specific breast cancer subtypes: findings from the Apolipoprotein Mortality Risk (AMORIS) cohort.Breast cancer research : BCR · 2017Article
- Metabolic markers in blood can separate prostate cancer from benign prostatic hyperplasia.British journal of cancer · 2015Article
- Impact of high glucose on metastasis of colon cancer cells.World journal of gastroenterology · 2015Article
- Metabolic serum biomarkers for the prediction of cancer: a follow-up of the studies conducted in the Swedish AMORIS study.Ecancermedicalscience · 2015Article
- The role of FAK in tumor metabolism and therapy.Pharmacology & therapeutics · 2014Review
- Prognostic Value of Handgrip Strength in Lung Cancer: Findings From a Multicenter Prospective Cohort Study.Cancer control : journal of the Moffitt Cancer CenterObservational
Corrections and comments
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Authors and funding
11 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundImpaired glucose metabolism has been linked with increased cancer risk, but the association between serum glucose and cancer risk remains unclear. We used repeated measurements of glucose and fructosamine to get more insight into the association between the glucose metabolism and risk of cancer.
methodsWe selected 11,998 persons (>20 years old) with four prospectively collected serum glucose and fructosamine measurements from the Apolipoprotein Mortality Risk (AMORIS) study. Multivariate Cox proportional hazards regression was used to assess standardized log of overall mean glucose and fructosamine in relation to cancer risk. Similar analyses were performed for tertiles of glucose and fructosamine and for different types of cancer.
resultsA positive trend was observed between standardized log overall mean glucose and overall cancer risk (HR= 1.08; 95% CI: 1.02-1.14). Including standardized log fructosamine in the model resulted in a stronger association between glucose and cancer risk and aninverse association between fructosamine and cancer risk (HR = 1.17; 95% CI: 1.08-1.26 and HR: 0.89; 95% CI: 0.82-0.96, respectively). Cancer risks were highest among those in the highest tertile of glucose and lowest tertile of fructosamine. Similar findings were observed for prostate, lung, and colorectal cancer while none observed for breast cancer.
conclusionThe contrasting effect between glucose, fructosamine, and cancer risk suggests the existence of distinct groups among those with impaired glucose metabolism, resulting in different cancer risks based on individual metabolic profiles. Further studies are needed to clarify whether glucose is a proxy of other lifestyle-related or metabolic factors.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.