ArticlePloS one2013
Identification of temporal and region-specific myocardial gene expression patterns in response to infarction in swine.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 29 citations in OpenAlex.
- Gene expression patterns and related pathways in the hearts of rhesus monkeys subjected to prolonged myocardial ischemia.Experimental biology and medicine (Maywood, N.J.) · 2023Article
- Article
- Cardiac protection by pirfenidone after myocardial infarction: a bioinformatic analysis.Scientific reports · 2022Article
- The Potential Anti-remodeling Effect of Paroxetine After Myocardial Infarction May Be Blunted by Beta-Blockers.Frontiers in cardiovascular medicine · 2022Article
- Deep Learning Analyses to Delineate the Molecular Remodeling Process after Myocardial Infarction.Cells · 2021Article
- Unraveling the Metabolic Derangements Occurring in Non-infarcted Areas of Pig Hearts With Chronic Heart Failure.Frontiers in cardiovascular medicine · 2021Article
- Human cardiac organoids for the modelling of myocardial infarction and drug cardiotoxicity.Nature biomedical engineering · 2020Article
- A Dynamic Transcriptional Analysis Reveals IL-6 Axis as a Prominent Mediator of Surgical Acute Response in Non-ischemic Mouse Heart.Frontiers in physiology · 2019Article
- Cardiac weights and weight ratios as indicators of cardiac lesions in pigs: A study of pig hearts from an Ontario abattoir.Canadian journal of veterinary research = Revue canadienne de recherche veterinaire · 2018Article
- Analysis of region specific gene expression patterns in the heart and systemic responses after experimental myocardial ischemia.Oncotarget · 2017Article
- Mechanisms of action of sacubitril/valsartan on cardiac remodeling: a systems biology approach.NPJ systems biology and applications · 2017Article
- A Multidisciplinary Assessment of Remote Myocardial Fibrosis After Reperfused Myocardial Infarction in Swine and Patients.Journal of cardiovascular translational research · 2016Article
- UM206, a selective Frizzled antagonist, attenuates adverse remodeling after myocardial infarction in swine.Laboratory investigation; a journal of technical methods and pathology · 2016Article
- miR-410 and miR-495 Are Dynamically Regulated in Diverse Cardiomyopathies and Their Inhibition Attenuates Pathological Hypertrophy.PloS one · 2016Article
- Postinfarction Functional Recovery Driven by a Three-Dimensional Engineered Fibrin Patch Composed of Human Umbilical Cord Blood-Derived Mesenchymal Stem Cells.Stem cells translational medicine · 2015Article
- Retinal transcriptome profiling at transcription start sites: a cap analysis of gene expression early after axonal injury.BMC genomics · 2014Article
- Profiles of extracellular miRNAs in the aqueous humor of glaucoma patients assessed with a microarray system.Scientific reports · 2014Article
- MicroRNAs in myocardial ischemia: identifying new targets and tools for treating heart disease. New frontiers for miR-medicine.Cellular and molecular life sciences : CMLS · 2014Review
- Engineered 3D bioimplants using elastomeric scaffold, self-assembling peptide hydrogel, and adipose tissue-derived progenitor cells for cardiac regeneration.American journal of translational research · 2014Article
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Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Molecular mechanisms associated with pathophysiological changes in ventricular remodelling due to myocardial infarction (MI) remain poorly understood. We analyzed changes in gene expression by microarray technology in porcine myocardial tissue at 1, 4, and 6 weeks post-MI.MI was induced by coronary artery ligation in 9 female pigs (30-40 kg). Animals were randomly sacrificed at 1, 4, or 6 weeks post-MI (n = 3 per group) and 3 healthy animals were also included as control group. Total RNA from myocardial samples was hybridized to GeneChip® Porcine Genome Arrays. Functional analysis was obtained with the Ingenuity Pathway Analysis (IPA) online tool. Validation of microarray data was performed by quantitative real-time PCR (qRT-PCR).More than 8,000 different probe sets showed altered expression in the remodelling myocardium at 1, 4, or 6 weeks post-MI. Ninety-seven percent of altered transcripts were detected in the infarct core and 255 probe sets were differentially expressed in the remote myocardium. Functional analysis revealed 28 genes de-regulated in the remote myocardial region in at least one of the three temporal analyzed stages, including genes associated with heart failure (HF), systemic sclerosis and coronary artery disease. In the infarct core tissue, eight major time-dependent gene expression patterns were recognized among 4,221 probe sets commonly altered over time. Altered gene expression of ACVR2B, BID, BMP2, BMPR1A, LMNA, NFKBIA, SMAD1, TGFB3, TNFRSF1A, and TP53 were further validated.The clustering of similar expression patterns for gene products with related function revealed molecular footprints, some of them described for the first time, which elucidate changes in biological processes at different stages after MI.
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