ArticlePloS one2013
High levels of genomic aberrations in serous ovarian cancers are associated with better survival.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- In silico generation of synthetic cancer genomes using generative AI.Cell genomics · 2025Article
- Inferring chromosomal instability from copy number aberrations as a measure of chromosomal instability across human cancers.Cancer reports (Hoboken, N.J.) · 2023Article
- Chromosomal instability and a deregulated cell cycle are intrinsic features of high-risk gastrointestinal stromal tumours with a metastatic potential.Molecular oncology · 2023Article
- Inferring chromosomal instability from copy number aberrations as a measure of chromosomal instability across human cancers.bioRxiv : the preprint server for biology · 2023Article
- Comprehensive characterization of tumor microenvironment in colorectal cancer via molecular analysis.eLife · 2023Article
- CINmetrics: an R package for analyzing copy number aberrations as a measure of chromosomal instability.PeerJ · 2023Article
- Medium levels of transcription and replication related chromosomal instability are associated with poor clinical outcome.Scientific reports · 2021Article
- Clinical relevance of TP53 hotspot mutations in high-grade serous ovarian cancers.British journal of cancer · 2020Article
- Blocking Mitotic Exit of Ovarian Cancer Cells by Pharmaceutical Inhibition of the Anaphase-Promoting Complex Reduces Chromosomal Instability.Neoplasia (New York, N.Y.) · 2019Article
- The expression of miRNAs is associated with tumour genome instability and predicts the outcome of ovarian cancer patients treated with platinum agents.Scientific reports · 2017Article
- The temporal dynamics of chromosome instability in ovarian cancer cell lines and primary patient samples.PLoS genetics · 2017Article
- High-grade serous ovarian cancer: the clone wars.Archives of gynecology and obstetrics · 2017Review
- Use of poly ADP-ribose polymerase [PARP] inhibitors in cancer cells bearing DDR defects: the rationale for their inclusion in the clinic.Journal of experimental & clinical cancer research : CR · 2016Review
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- Detection of high mobility group A2 specific mRNA in the plasma of patients affected by epithelial ovarian cancer.Oncotarget · 2015Article
- Deletion at 6q24.2-26 predicts longer survival of high-grade serous epithelial ovarian cancer patients.Molecular oncology · 2015Article
- Correlation between gene expression and mutator phenotype predicts homologous recombination deficiency and outcome in ovarian cancer.Journal of molecular medicine (Berlin, Germany) · 2014Article
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17 authors.
Funding
Abstract
Genomic instability and copy number alterations in cancer are generally associated with poor prognosis; however, recent studies have suggested that extreme levels of genomic aberrations may be beneficial for the survival outcome for patients with specific tumour types. We investigated the extent of genomic instability in predominantly high-grade serous ovarian cancers (SOC) using two independent datasets, generated in Norway (n = 74) and Australia (n = 70), respectively. Genomic instability was quantified by the Total Aberration Index (TAI), a measure of the abundance and genomic size of copy number changes in a tumour. In the Norwegian cohort, patients with TAI above the median revealed significantly prolonged overall survival (p<0.001) and progression-free survival (p<0.05). In the Australian cohort, patients with above median TAI showed prolonged overall survival (p<0.05) and moderately, but not significantly, prolonged progression-free survival. Results were confirmed by univariate and multivariate Cox regression analyses with TAI as a continuous variable. Our results provide further evidence supporting an association between high level of genomic instability and prolonged survival of high-grade SOC patients, possibly as disturbed genome integrity may lead to increased sensitivity to chemotherapeutic agents.
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