ArticlePloS one2013
Lack of RsmA-mediated control results in constant hypervirulence, cell elongation, and hyperflagellation in Pectobacterium wasabiae.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 27 citations in OpenAlex.
- Multimodal Inhibition ofJournal of agricultural and food chemistry · 2025Article
- An OFrontiers in microbiology · 2023Article
- Genome Wide Analysis of the Potato Soft Rot Pathogen Pectobacterium carotovorum Strain ICMP 5702 to Predict Novel Insights into Its Genetic Features.The plant pathology journal · 2022Article
- Phloretin, an Apple Phytoalexin, Affects the Virulence and Fitness ofFrontiers in plant science · 2021Article
- Stereoisomers of the Bacterial Volatile Compound 2,3-Butanediol Differently Elicit Systemic Defense Responses of Pepper against Multiple Viruses in the Field.Frontiers in plant science · 2018Article
- The RNA-binding protein CsrA plays a central role in positively regulating virulence factors in Erwinia amylovora.Scientific reports · 2016Article
- Plant phenolic acids affect the virulence of Pectobacterium aroidearum and P. carotovorum ssp. brasiliense via quorum sensing regulation.Molecular plant pathology · 2016Article
- Sweet scents from good bacteria: Case studies on bacterial volatile compounds for plant growth and immunity.Plant molecular biology · 2016Review
- The trans-kingdom identification of negative regulators of pathogen hypervirulence.FEMS microbiology reviews · 2016Review
- Microbial population dynamics in response to Pectobacterium atrosepticum infection in potato tubers.Scientific reports · 2015Article
- Regulation of bacterial virulence by Csr (Rsm) systems.Microbiology and molecular biology reviews : MMBR · 2015Review
- The global response regulator ExpA controls virulence gene expression through RsmA-mediated and RsmA-independent pathways in Pectobacterium wasabiae SCC3193.Applied and environmental microbiology · 2014Article
- The ribonucleoprotein Csr network.International journal of molecular sciences · 2013Review
- Role and regulation of the Flp/Tad pilus in the virulence of Pectobacterium atrosepticum SCRI1043 and Pectobacterium wasabiae SCC3193.PloS one · 2013Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The posttranscriptional regulator RsmA controls the production of plant cell wall degrading enzymes (PCWDE) and cell motility in the Pectobacterium genus of plant pathogens. In this study the physiological role of gene regulation by RsmA is under investigation. Disruption of rsmA gene of the Pectobacterium wasabiae strain, SCC3193 resulted in 3-fold decrease in growth rate and increased virulence. The comparison of mRNA levels of the rsmA(-) mutant and wild-type using a genome-wide microarray showed, that genes responsible for successful infection, i.e. virulence factors, motility, butanediol fermentation, various secretion systems etc. were up-regulated in the rsmA(-) strain. The rsmA(-) strain exhibited a higher propensity to swarm and produce PCWDE compared to the wild-type strain. Virulence experiments in potato tubers demonstrated that in spite of its more efficient tissue maceration, the rsmA(-) strain's ability to survive within the host is reduced and the infection site is taken over by resident bacteria. Taken together, in the absence of RsmA, cells revert to a constitutively infective phenotype characterized by expression of virulence factors and swarming. We hypothesize that lack of control over these costly energetic processes results in decreased growth rate and fitness. In addition, our findings suggest a relationship between swarming and virulence in plant pathogens.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.