SynthesisJournal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine2013
Effect of oral appliances on blood pressure in obstructive sleep apnea: a systematic review and meta-analysis.
Synthesis in Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
34 citing papers in PubMed, 3 syntheses or guidelines pooled it, 134 citations in OpenAlex.
- Mandibular advancement devices decrease systolic pressure during the day and night in patients with obstructive sleep apnea: A systematic review and meta-analysis.Sleep & breathing = Schlaf & Atmung · 2024Pooled it
- Quality Assessment of Systematic Reviews on the Efficacy of Oral Appliance Therapy for Adult and Pediatric Sleep-Disordered Breathing.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2016Pooled it
- Pooled it
- The treatment of mild OSA with CPAP or mandibular advancement device and the effect on blood pressure and endothelial function after one year of treatment.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2021Trial
- Beyond Sleep: The Cardiovascular Impact of Obstructive Sleep Apnea Syndrome.Journal of clinical medicine · 2026Article
- When the Heart Meets the Pillow: Building Cross-disciplinary Solutions for Sleep-disordered Breathing.Cardiac failure review · 2026Review
- Mandibular Advancement Devices for Obstructive Sleep Apnea: Bibliometric Analysis (1984-2024).Nature and science of sleep · 2025Article
- Effectiveness of Narval CC™ device in the treatment of obstructive sleep apnea.Sleep medicine: X · 2023Article
- Oral appliance therapy for obstructive sleep apnea: a retrospective study in a psychiatric sleep clinic.Fujita medical journal · 2023Article
- Obstructive Sleep Apnea and Cardiovascular Disease: Where Do We Stand?Anatolian journal of cardiology · 2023Review
- A Narrative Review of the Association of Obstructive Sleep Apnea with Hypertension: How to Treat Both When They Coexist?Journal of clinical medicine · 2023Review
- Effectiveness of Titratable Oral Appliance in Management of Moderate to Severe Obstructive Sleep Apnea-A Prospective Clinical Study with Acoustic Pharyngometry.Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India · 2022Article
- The long-term impact of expansion sphincter pharyngoplasty treatment on blood pressure control and health-related quality of life in patients with obstructive sleep apnea and hypertension.Sleep & breathing = Schlaf & Atmung · 2021Article
- Review of systematic reviews on mandibular advancement oral appliance for obstructive sleep apnea: The importance of long-term follow-up.The Japanese dental science review · 2020Review
- Treating sleep disorders to improve blood pressure control and cardiovascular prevention: a dream come true?-a narrative review.Journal of thoracic disease · 2020Review
- Obstructive Sleep Apnea and Hypertension: A Review of the Relationship and Pathogenic Association.Cureus · 2020Review
- Update on oral appliance therapy.European respiratory review : an official journal of the European Respiratory Society · 2019Review
- Review
- Sleep and Stroke: New Updates on Epidemiology, Pathophysiology, Assessment, and Treatment.Current sleep medicine reports · 2019Article
- Observational
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundObstructive sleep apnea (OSA) is an independent risk factor for the development of hypertension. However the effect of continuous positive airway pressure (CPAP) on lowering systemic blood pressure (BP) in OSA patients has been conflicting. Oral appliance (OA) therapy is an important alternative therapy to CPAP for patients with mild to moderate OSA.
objectiveTo conduct a meta-analysis of studies which have evaluated the effect of OAs on BP in patients with OSA. DATA SOURCES: Studies were retrieved by searching PubMed (all studies that were published until December 15, 2011) STUDY SELECTION: Three independent reviewers screened citations to identify trials of the effect of OA on BP. DATA EXTRACTION: Data from observational and randomized controlled trial (RCT) studies was extracted for pre- and post-treatment systolic, diastolic, and mean arterial blood pressure (SBP, DBP, and MAP). DATA SYNTHESIS: A total of 7 studies that enrolled 399 participants met the inclusion criteria. The pooled estimate of mean changes and the corresponding 95% CIs for SBP, DBP, and MAP from each trial are -2.7 mm Hg (95% CI: -0.8 to -4.6), p-value 0.04; -2.7 mm Hg (95% CI: -0.9 to -4.6), p-value 0.004; and -2.40 mm Hg (95% CI: -4.01 to -0.80), p-value 0.003 (Figures 2-4). The pooled estimate of mean changes and the corresponding 95% CIs for nocturnal SBP, DBP, and MAP from each trial are -2.0 mm Hg (95% CI: 1.1 to -5.3), p-value 0.212; -1.7 mm Hg (95% CI: -0.1 to -3.2), p-value 0.03; and -1.9 mm Hg (95% CI: 1.3 to -5.1), p-value 0.255 (Figures 5-7) respectively.
conclusionsThe pooled estimate shows a favorable effect of OAs on SBP, MAP, and DBP. Most of the studies were observational. Therefore, more RCTs are warranted involving a larger number of patients and longer treatment periods to confirm the effects of OA on BP.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.