ArticleInternational journal of medical sciences2013
Detection of hypermethylated spastic paraplegia-20 in stool samples of patients with colorectal cancer.
Article in International journal of medical sciences, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 5 of them syntheses that pooled it.
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Who cites it
18 citing papers in PubMed, 5 syntheses or guidelines pooled it, 32 citations in OpenAlex.
- DNA methylation markers detected in blood, stool, urine, and tissue in colorectal cancer: a systematic review of paired samples.International journal of colorectal disease · 2021Pooled it
- Fecal DNA methylation markers for detecting stages of colorectal cancer and its precursors: a systematic review.Clinical epigenetics · 2020Pooled it
- The importance of stool DNA methylation in colorectal cancer diagnosis: A meta-analysis.PloS one · 2018Pooled it
- The Diagnostic Performance of Stool DNA Testing for Colorectal Cancer: A Systematic Review and Meta-Analysis.Medicine · 2016Pooled it
- Accuracy of early detection of colorectal tumours by stool methylation markers: a meta-analysis.World journal of gastroenterology · 2014Pooled it
- A scoping review of DNA methylation biomarkers for non-invasive detection of colorectal cancer at the CpG site level.Clinical epigenetics · 2026Article
- Epigenetic Alteration in Colorectal Cancer: Potential Diagnostic and Prognostic Implications.International journal of molecular sciences · 2024Review
- Methylation of FBN1, SPG20, ITF2, RUNX3, SNCA, MLH1, and SEPT9 genes in circulating cell-free DNA as biomarkers of colorectal cancer.Cancer biomarkers : section A of Disease markers · 2022Article
- Article
- Identification of prognostic genes in colorectal cancer through transcription profiling of multi-stage carcinogenesis.Oncology letters · 2019Article
- Detection of SPG20 gene promoter-methylated DNA, as a novel epigenetic biomarker, in plasma for colorectal cancer diagnosis using the MethyLight method.Oncology letters · 2017Article
- Identification of diagnostic markers in colorectal cancer via integrative epigenomics and genomics data.Oncology reports · 2015Article
- Detection of SNCA and FBN1 methylation in the stool as a biomarker for colorectal cancer.Disease markers · 2015Article
- Colorectal cancer: from prevention to personalized medicine.World journal of gastroenterology · 2014Review
- Detection of miR-34a and miR-34b/c in stool sample as potential screening biomarkers for noninvasive diagnosis of colorectal cancer.Medical oncology (Northwood, London, England) · 2014Article
- Detection of aberrant hypermethylated spastic paraplegia-20 as a potential biomarker and prognostic factor in gastric cancer.Medical oncology (Northwood, London, England) · 2014Article
- Cell-free nucleic acids as noninvasive biomarkers for colorectal cancer detection.Frontiers in genetics · 2014Review
- Detection of hypermethylated fibrillin-1 in the stool samples of colorectal cancer patients.Medical oncology (Northwood, London, England) · 2013Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAnalysis of aberrant hypermethylation in stool DNA might provide a novel strategy for noninvasive detection of colorectal cancer.
aimsTo explore the feasibility of detecting hypermethylation in Spastic paraplegia-20 promoter as a stool-based DNA marker for detection of colorectal cancer.
methodsWe collected 96 tissue and stool samples from patients with colorectal cancer and 30 stool samples healthy individuals.
resultsHypermethylated Spastic paraplegia-20 occurs in 85.4% (82/96) of patients with colorectal cancer in the tissue samples. In the stool samples, the results indicate 80.2% (77/96) sensitivity and 100% (30/30) specificity of the test for detecting colorectal cancer by using the stool samples as a noninvasive method.
conclusionsThe study reveals that hypermethylation in Spastic paraplegia-20 promoter is a highly specific and sensitive biomarker for screening colorectal cancer in stool samples as a noninvasive method.
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