Evidence map›Paper›PMID 23372267›Full record

ArticleSleep2013

Association between GABA(A) receptor subunit gene cluster and zolpidem-induced complex sleep behaviors in Han Chinese.

Jui-Hsiu Tsai, Pinchen Yang, Hung-Hsun Lin, Kuang-Hung Cheng, Yi-Hsin Yang, Ming-Tsang Wu, Cheng-Chung Chen

Open access · bronzeAbstract read
In one paragraph

Article in Sleep, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.1field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 6 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

Jui-Hsiu TsaiDepartment of Psychiatry, Kaohsiung Municipal Ta-Tung Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan.
Pinchen Yang
Hung-Hsun Lin
Kuang-Hung Cheng
Yi-Hsin Yang
Ming-Tsang Wu
Cheng-Chung Chen
Kaohsiung Medical University · TWKaohsiung Municipal Hsiao-Kang Hospital · TWKaohsiung Municipal Kai-Syuan Psychiatric Hospital · TWNational Sun Yat-sen University · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

STUDY

objectivesTo investigate and elucidate the role of GABA(A) receptor subunits, specifically the 2 genetic markers at the GABA(A) α1 and GABA(A) α6 receptors, in zolpidem-induced complex sleep behaviors (CSBs).

designGenetic association study.

settingKaohsiung Medical University-affiliated hospitals, Kaohsiung, Taiwan. PATIENTS: 30 zolpidem-induced CSB subjects and 37 controls.

interventionsN/A. MEASUREMENTS AND

resultsThe χ(2) test demonstrated an association between the A15G variant at the GABA(A) α1 receptor subunit gene and zolpidem-induced CSBs (P = 0.007). The adjusted odds ratio of the GABA(A) α1 receptor subunit genotype for the risk of zolpidem-induced CSBs was approximately 10 (OR = 9.99, 95% CI = 1.82, 74.87; P = 0.013).

conclusionsThe finding reveals that the A15G variant at the GABA(A) α1 receptor subunit gene confers a high risk of zolpidem-induced CSBs and may be considered in clinical services.

Indexed as

AdultAsian PeopleCase-Control StudiesFemaleGenetic Association StudiesGenetic MarkersGenotypeHumansHypnotics and SedativesMaleMiddle AgedMultigene FamilyPoint MutationPyridinesReceptors, GABA-ASleepGABRA1 protein, humanGenetic MarkersHypnotics and SedativesPyridinesReceptors, GABA-AZolpidem

Identifiers

PMID23372267
PMCPMC3543054
OpenAlexW2316917755

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.