ArticleClinical journal of the American Society of Nephrology : CJASN2013
Precision of estimating equations for GFR in children with a solitary functioning kidney: the KIMONO study.
Article in Clinical journal of the American Society of Nephrology : CJASN, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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27 citing papers in PubMed, 41 citations in OpenAlex.
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- Early identification of CKD in patients with solitary functioning kidney.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2025Article
- Comparison of estimated GFR using cystatin C versus creatinine in pediatric kidney transplant recipients.Pediatric nephrology (Berlin, Germany) · 2024Article
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- Multidisciplinary approaches for elucidating genetics and molecular pathogenesis of urinary tract malformations.Kidney international · 2022Review
- The spectrum of kidney function alterations in adolescents with a solitary functioning kidney.Pediatric nephrology (Berlin, Germany) · 2021Article
- Clinical Management of Children with a Congenital Solitary Functioning Kidney: Overview and Recommendations.European urology open science · 2021Review
- Proteinuria-take a closer look!Pediatric nephrology (Berlin, Germany) · 2020Review
- Towards adulthood with a solitary kidney.Pediatric nephrology (Berlin, Germany) · 2019Review
- Current Management of Patients With Acquired Solitary Kidney.Kidney international reports · 2019Review
- Consensus recommendations for diagnosis, management and treatment of Fabry disease in paediatric patients.Clinical genetics · 2019Article
- Validation of standardized creatinine and cystatin C GFR estimating equations in a large multicentre European cohort of children.Pediatric nephrology (Berlin, Germany) · 2019Article
- Comparison of long-term kidney functions after radical nephrectomy and simple nephrectomy.PeerJ · 2019Article
- Correlation between hypertrophy and risk of hypertension in congenital solitary functioning kidney.Pediatric surgery international · 2019Article
- GFR-estimation by serum creatinine during glucocorticosteroid therapy.Clinical and experimental nephrology · 2018Article
- Combining GFR estimates from cystatin C and creatinine-what is the optimal mix?Pediatric nephrology (Berlin, Germany) · 2018Article
- Multicenter Laboratory Comparison of Iohexol Measurement.The journal of applied laboratory medicine · 2018Article
- Validation of serum creatinine-based formulae in pediatric renal transplant recipients.Pediatric research · 2017Article
- Prospective analysis of long-term renal function in survivors of childhood Wilms tumor.Pediatric nephrology (Berlin, Germany) · 2017Article
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6 authors at 3 institutions in 2 countries.
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No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND AND
objectiveChildren with a solitary functioning kidney may develop CKD. Although widely used, equations to estimate GFR are not validated in these patients. This study sought to determine the precision of common estimating equations in the KIMONO (KIdney of MONofunctional Origin) cohort. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: Two creatinine-based (estimated GFR [eGFR]-Schwartz, urinary creatinine clearance), two cystatin C-based (eGFR-Zappitelli1, eGFR-CKiD [Chronic Kidney Disease in Children] 1), and two cystatin C/creatinine-based (eGFR-Zappitelli2, eGFR-CKiD2) estimates were compared with the gold standard GFR measured by inulin single injection (GFR-inulin) in 77 children with a solitary functioning kidney (time span of assembly, 2005-2012). Included patients were 1.5-19.8 years of age. Kidney Disease Outcomes Quality Initiative (K/DOQI) classification was compared between GFR-inulin and eGFR methods to analyze misclassification by estimating equations.
resultsThe eGFR-CKiD2 equation performed best in children with a solitary functioning kidney (mean bias, -0.9 ml/min per 1.73 m(2); 95% and 54% of values within ±30% and ±10% of GFR-inulin, respectively). Mean bias for eGFR-Schwartz was 0.4 ml/min per 1.73 m(2), with 90% and 33% of values within ±30% and ±10% of GFR-inulin, respectively. For all estimates, misclassification in K/DOQI stage ranged from 22% (eGFR-Zappitelli1) to 44% (urinary creatinine clearance) of children.
conclusionsUse of a combined serum cystatin C/creatinine-based equation (eGFR-CKiD2) is recommended to monitor renal function in children with a solitary functioning kidney. When cystatin C is not routinely available, eGFR-Schwartz should be used. Misclassification in K/DOQI-stage remains a caveat for all equations.
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