ArticleCirculation research2013
Thymosin β4 is not required for embryonic viability or vascular development.
Article in Circulation research, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed, 15 citations in OpenAlex.
- Review
- Spatiotemporal single-cell RNA sequencing of developing chicken hearts identifies interplay between cellular differentiation and morphogenesis.Nature communications · 2021Article
- Epicardial Contribution to the Developing and Injured Heart: Exploring the Cellular Composition of the Epicardium.Frontiers in cardiovascular medicine · 2021Review
- Tβ4-Ac-SDKP pathway: Any relevance for the cardiovascular system?Canadian journal of physiology and pharmacology · 2019Review
- No effect of thymosin beta-4 on the expression of the transcription factor Islet-1 in the adult murine heart.Pharmacology research & perspectives · 2018Article
- Does cardiac development provide heart research with novel therapeutic approaches?F1000Research · 2018Review
- Expression and localisation of thymosin beta-4 in the developing human early fetal heart.PloS one · 2018Article
- Cyclin A2 modulates kinetochore-microtubule attachment in meiosis II.The Journal of cell biology · 2017Article
- Cardiac regeneration: epicardial mediated repair.Proceedings. Biological sciences · 2015Review
- Cellular origin and developmental program of coronary angiogenesis.Circulation research · 2015Review
- Thymosin Beta-4 Induces Mouse Hair Growth.PloS one · 2015Article
- New vessel formation in the context of cardiomyocyte regeneration--the role and importance of an adequate perfusing vasculature.Stem cell research · 2014Review
- The epicardium signals the way towards heart regeneration.Stem cell research · 2014Review
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
rationaleRossdeutsch et al describe a requirement for thymosin β4 (Tβ4) in vascular development. Impaired mural cell migration, differentiation, partial embryonic lethality, and hemorrhaging were observed after analysis of 2 lines of mice, one of which was germline null for Tβ4 and another in which Tβ4 was knocked down by endothelial-specific expression of Tβ4 short hairpin RNA. These data are in direct contrast to our published global and cardiac-specific Tβ4-knockout lines. Thus, the role of Tβ4 needs to be clarified to understand its importance in cardiovascular development.
objectiveTo investigate and clarify the role of Tβ4 in vascular smooth muscle cell development and vessel stability. METHODS AND
resultsExamination of Tβ4 global knockouts did not demonstrate embryonic hemorrhaging, altered mural cell development, or lethality. Endothelial-specific knockouts also did not exhibit any embryonic lethality and were viable to adulthood.
conclusionsAnalysis of our Tβ4 global and cardiac- and endothelial-specific knockout models demonstrated that Tβ4 is dispensable for embryonic viability and vascular development.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.