ReviewJournal of assisted reproduction and genetics2013
New molecular markers for the evaluation of gamete quality.
Review in Journal of assisted reproduction and genetics, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 3 syntheses or guidelines pooled it, 60 citations in OpenAlex.
- Biomarker candidates for oocyte and embryo quality assessment in assisted reproduction: A systematic review.JBRA assisted reproduction · 2025Pooled it
- Meta-correlation of Sperm Morphology and DNA Fragmentation Index.Reproductive sciences (Thousand Oaks, Calif.) · 2025Pooled it
- A systematic review and meta-analysis to determine the effect of sperm DNA damage onAsian journal of andrologyPooled it
- Relationship Between Vitamin D Level and DNA Fragmentation Index of Sperm in Men Referred to Omid Infertility Center in Hamadan-Iran: A Cross-Sectional Study.Journal of family & reproductive health · 2025Article
- AKT, p-AKT, ERK1/2 and p-ERK1/2 in Mural Granulosa Cells Are Not Correlated to Different Ovarian Stimulation Protocols in Patients Undergoing Assisted Reproductive Treatment.Life (Basel, Switzerland) · 2024Article
- Sperm DNA Fragmentation and Sperm-Borne miRNAs: Molecular Biomarkers of Embryo Development?International journal of molecular sciences · 2023Article
- Effects of Au@Ag core-shell nanostructure with alginate coating on male reproductive system in mice.Toxicology reports · 2023Article
- Human Papillomavirus (HPV) Infection and Its Impact on Male Infertility.Life (Basel, Switzerland) · 2022Article
- Methods for Assessing Oocyte Quality: A Review of Literature.Biomedicines · 2022Review
- An Update on Semen Physiology, Technologies, and Selection Techniques for the Advancement of In Vitro Equine Embryo Production: Section II.Animals : an open access journal from MDPI · 2021Review
- The Effect of Non-Thermal Plasma on the Structural and Functional Characteristics of Human Spermatozoa.International journal of molecular sciences · 2021Article
- Oocyte Competence Biomarkers Associated With Oocyte Maturation: A Review.Frontiers in cell and developmental biology · 2021Review
- Oocyte Selection for In Vitro Embryo Production in Bovine Species: Noninvasive Approaches for New Challenges of Oocyte Competence.Animals : an open access journal from MDPI · 2020Review
- Sperm DNA Fragmentation: A New Guideline for Clinicians.The world journal of men's health · 2020Review
- Predicting The Developmental Potential Of Cleavage Stage Embryos Based On Oxygen Consumption Rate In FET Cycles.JBRA assisted reproduction · 2020Article
- HPV infection in semen: results from a new molecular approach.Epidemiology and infection · 2019Article
- Paternal factors contributing to embryo quality.Journal of assisted reproduction and genetics · 2018Review
- Cumulus cells surrounding oocytes with high developmental competence exhibit down-regulation of phosphoinositol 1,3 kinase/protein kinase B (PI3K/AKT) signalling genes involved in proliferation and survival.Human reproduction (Oxford, England) · 2017Article
- Cyclic AMP-elevating Agents Promote Cumulus Cell Survival and Hyaluronan Matrix Stability, Thereby Prolonging the Time of Mouse Oocyte Fertilizability.The Journal of biological chemistry · 2016Article
- Impact of sperm DNA chromatin in the clinic.Journal of assisted reproduction and genetics · 2016Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeOnly 30 % of IVF cycles result in a pregnancy, so that multiple embryos need to be replaced, per treatment cycle, to increase pregnancy rates, resulting in a multiple gestation rate of 25 %. The use of new markers in the gamete selection, could reduce the number of the oocytes to be fertilized and embryos to be produced, but the tools to evidence the gamete competence remain unavailable and more studies are needed to identify bio-markers to select the best oocyte and sperm to produce embryos with higher implantation potentiality.
methodsTo define oocyte competence, the apoptosis of the surrounding cumulus cells and the oxygen consumption rates for individual oocytes before fertilization seems to provide a non-invasive marker of oocyte competence and hence a quantitative assessment of the reproductive potential for the oocyte. The chromatin integrity seems to be used also as biological marker of sperm competence, together with the morphological evaluation of large vacuoles in the head.
resultsThe apoptosis rate of cumulus cells lower than 25 % and an higher oxygen consumption could be an evidence of an overall metabolic activity, related to a better fertilization ability and embryo cleavage quality. The apoptosis rate of the sperm chromatin, evaluated by direct Tunel in situ analysis, seems to be, also for the male gamete, a marker of competence and implantation potentiality, in particular when it is lower than 20 %. The evaluation of the presence of large vacuoles in the sperm head prior to perform ICSI seems to increase the implantation rate, but it is not associated to chromatin integrity.
conclusionsThe biological concept of competence appears unrelated to any morphological parameters, so that it is necessary to investigate new molecular markers in the gamete selection. Apoptosis of cumulus cells in the oocytes and spermatozoa, revealing the presence of large vacuoles, could help to determine the competence of the gamete to be fertilize.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.