ArticleJournal of neuro-oncology2013
Supra- and infratentorial pediatric ependymomas differ significantly in NeuN, p75 and GFAP expression.
Article in Journal of neuro-oncology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
8 citing papers in PubMed, 14 citations in OpenAlex.
- Neurotrophin Signaling in Medulloblastoma.Cancers · 2020Review
- Prognostic and microRNA profile analysis for CD44 positive expression pediatric posterior fossa ependymoma.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2018Article
- Neuronal Activity in Ontogeny and Oncology.Trends in cancer · 2017Review
- The Similarities and Differences between Intracranial and Spinal Ependymomas : A Review from a Genetic Research Perspective.Journal of Korean Neurosurgical Society · 2016Review
- Proteomic and Mitochondrial Genomic Analyses of Pediatric Brain Tumors.Molecular neurobiology · 2015Article
- Pancreatic cancer patient survival correlates with DNA methylation of pancreas development genes.PloS one · 2015Article
- Cartilage differentiation in ependymoma: histogenetic considerations on a new case.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2014Article
- Article
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Ependymomas comprise 8 % of all intracranial tumors in children <15 years. Recent studies revealed that some supratentorial ependymomas express neuronal antigens and that high expression of neurofilament protein light polypeptide (NEFL) correlates with better clinical outcome. We retrospectively analyzed an expanded panel of proteins in 6 supratentorial, 15 posterior fossa and 4 spinal pediatric ependymomas by immunohistochemistry. Expression of high and low affinity neurotrophin receptors TrkA (NTRK1) and p75 (NGFR), pan-neuronal markers NeuN (RBFOX3) and synaptophysin, radial glial marker SOX9, adhesion molecules CD56 (NCAM) and CD44, junctional protein connexin 43 (GJA1), glial fibrillary acidic protein (GFAP), epithelial membrane antigen and proliferation associated antigen Ki-67 were evaluated in a semi-quantitative or quantitative (Ki-67 and NeuN-index) fashion. We found p75 and NeuN to be expressed at significantly higher levels in supratentorial versus infratentorial tumors and GFAP to be expressed at significantly higher levels in infratentorial lesions. In conclusion, immunohistochemical expression of p75, NeuN and GFAP differed in ependymomas depending on tumor topography supporting the view of divergent cells of origin. However, because of the small sample size the results are of preliminary nature and replication in a larger cohort would be desirable.
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