ArticleArthritis care & research2013
Significance of palpable tendon friction rubs in early diffuse cutaneous systemic sclerosis.
Article in Arthritis care & research, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
19 citing papers in PubMed, 56 citations in OpenAlex.
- Review
- Evaluation of Systemic Sclerosis Primary Heart Involvement and Chronic Heart Failure in the European Scleroderma Trials and Research Cohort.Journal of the American Heart Association · 2025Article
- Anti-Th/To Antibodies in Scleroderma: Good Prognosis or Serious Concern?Journal of clinical medicine · 2024Review
- A data-driven approach finds RNA polymerase III antibody and tendon friction rubs as enrichment tools for early diffuse scleroderma trials.Rheumatology (Oxford, England) · 2023Article
- Considerations for Hand Surgery in Patients With Scleroderma.Hand (New York, N.Y.) · 2023Review
- Development of Pulmonary Hypertension in Over One-Third of Patients With Th/To Antibody-Positive Scleroderma in Long-Term Follow-Up.Arthritis & rheumatology (Hoboken, N.J.) · 2022Article
- Musculoskeletal ultrasound of the shoulder in systemic sclerosis.Journal of scleroderma and related disorders · 2022Article
- The Role of the Multidisciplinary Health Care Team in the Management of Patients with Systemic Sclerosis.Journal of multidisciplinary healthcare · 2022Review
- Journey of a patient with scleroderma from renal failure up to kidney transplantation.World journal of transplantation · 2021Review
- Clinical characteristics, visceral involvement, and mortality in at-risk or early diffuse systemic sclerosis: a longitudinal analysis of an observational prospective multicenter US cohort.Arthritis research & therapy · 2021Observational
- Worsening of esophageal dilatation is associated with increase in a high-resolution computed tomography (HRCT) score in early systemic sclerosis-associated interstitial lung disease (SSc-ILD).Clinical rheumatology · 2021Article
- Association of Musculoskeletal and Radiological Features with Clinical and Serological Findings in Systemic Sclerosis: A Single-Centre Registry Study.Mediterranean journal of rheumatology · 2020Article
- Biomarkers in systemic sclerosis.Current opinion in rheumatology · 2019Review
- Serum YKL-40 and IL-6 levels correlate with ultrasound findings of articular and periarticular involvement in patients with systemic sclerosis.Rheumatology international · 2019Article
- Scleroderma renal crisis: a review for emergency physicians.Internal and emergency medicine · 2019Review
- Scleroderma renal crisis and renal involvement in systemic sclerosis.Nature reviews. Nephrology · 2016Review
- Hand Impairment in Systemic Sclerosis: Various Manifestations and Currently Available Treatment.Current treatment options in rheumatology · 2016Article
- Survival and causes of death in systemic sclerosis patients: a single center registry report from Iran.Rheumatology international · 2016Article
- Treatment of Rapidly Progressive Systemic Sclerosis: Current and Futures Perspectives.Expert opinion on orphan drugs · 2016Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
objectivePalpable tendon friction rubs (TFRs) in systemic sclerosis (SSc; scleroderma) have been associated with diffuse skin thickening, increased disability, and poor survival. Our objective was to quantify the prognostic implications of palpable TFRs on the development of disease complications and longer-term mortality in an incident cohort of early diffuse cutaneous SSc (dcSSc) patients.
methodsWe identified early dcSSc patients (disease duration <2 years from the first SSc symptom) first evaluated at the University of Pittsburgh Scleroderma Center between 1980 and 2006 and found to have palpable TFRs. These patients were matched 1:1 with the next consecutive early dcSSc patient without TFRs as a control. All had ≥2 clinic visits and 5 years of followup from the first visit.
resultsA total of 287 early dcSSc patients with TFR were identified and matched to 287 controls. The median disease duration was 0.83 years in TFR patients and 1.04 years in controls. The median followup was 10.1 years in TFR patients and 7.9 years in controls. Over the course of their illness, patients with TFRs had a >2-fold risk of developing renal crisis and cardiac and gastrointestinal disease complications, even after adjustment for other known risk factors. Patients with TFRs had poorer 5- and 10-year survival rates.
conclusionPatients with early dcSSc having ≥1 TFRs are at an increased risk of developing renal, cardiac, and gastrointestinal involvement before and after their first Scleroderma Center visit and have reduced survival. Patients presenting with TFRs should be carefully monitored for serious internal organ involvement.
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