ArticleBehavior genetics2013
Functional mapping of the neuronal substrates for drug tolerance in Drosophila.
Article in Behavior genetics, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 19 citations in OpenAlex.
- SWI/SNF complexes modulate gene expression and the development of physical dependence to ethanol.Alcohol, clinical & experimental research · 2026Article
- The non-nuclear DifB NF-κB isoform affects courtship, circadian, and locomotor behavior in adultFrontiers in behavioral neuroscience · 2025Article
- Alcohol sensitivity and tolerance encoding in sleep regulatory circadian neurons in Drosophila.Addiction biology · 2023Article
- Alcohol tolerance encoding in sleep regulatory circadian neurons in Drosophila.bioRxiv : the preprint server for biology · 2023Article
- Sleep Modulates Alcohol Toxicity inInternational journal of molecular sciences · 2022Article
- Excitatory and inhibitory neural dynamics jointly tune motion detection.Current biology : CB · 2022Article
- TheJournal of neurogenetics · 2021Article
- Flying Together:International journal of molecular sciences · 2020Review
- Normal Ethanol Sensitivity and Rapid Tolerance Require the G Protein Receptor Kinase 2 in Ellipsoid Body Neurons in Drosophila.Alcoholism, clinical and experimental research · 2020Article
- Studying alcohol use disorder using Drosophila melanogaster in the era of 'Big Data'.Behavioral and brain functions : BBF · 2019Review
- Automated real-time quantification of group locomotor activity in Drosophila melanogaster.Scientific reports · 2019Article
- Mechanisms Underlying the Risk to Develop Drug Addiction, Insights From Studies inFrontiers in physiology · 2018Review
- Shared neurocircuitry underlying feeding and drugs of abuse in Drosophila.Biomedical journal · 2015Review
- SWI/SNF chromatin remodeling regulates alcohol response behaviors in Caenorhabditis elegans and is associated with alcohol dependence in humans.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- The role of clock in ethanol-related behaviors.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2013Article
- BK channels and alcohol tolerance: Insights from studies onMedicine internationalArticle
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Physical dependence on alcohol and anesthetics stems from neuroadaptive changes that act to counter the effects of sedation in the brain. In Drosophila, exposure to either alcohol or solvent anesthetics have been shown to induce changes in expression of the BK-type Ca(2+)-activated K(+) channel gene slo. An increase in slo expression produces an adaptive modulation of neural activity that generates resistance to sedation and promotes drug tolerance and dependence. Increased BK channel activity counteracts the sedative effects of these drugs by reducing the neuronal refractory period and enhancing the capacity of neurons for repetitive firing. However, the brain regions or neuronal populations capable of producing inducible resistance or tolerance remain unknown. Here we map the neuronal substrates relevant for the slo-dependent modulation of drug sensitivity. Using spatially-controlled induction of slo expression we identify the mushroom bodies, the ellipsoid body and a subset of the circadian clock neurons as pivotal regions for the control of recovery from sedation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.