ArticleInternational journal of clinical oncology2014
Limitation of indocyanine green fluorescence in identifying sentinel lymph node prior to skin incision in cutaneous melanoma.
Article in International journal of clinical oncology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 47 citations in OpenAlex.
- Emerging Nanotheranostics for 5-Fluorouracil in Cancer Therapy: A Systematic Review on Efficacy, Safety, and Diagnostic Capability.Frontiers in pharmacology · 2022Pooled it
- Sentinel Lymph Node Procedure in Pediatric Patients with Melanoma, Squamous Cell Carcinoma, or Sarcoma Using Near-Infrared Fluorescence Imaging with Indocyanine Green: A Feasibility Trial.Annals of surgical oncology · 2023Trial
- Positron Lymphography via IntracervicalJournal of nuclear medicine : official publication, Society of Nuclear Medicine · 2020Trial
- Evaluation of a radioactive and fluorescent hybrid tracer for sentinel lymph node biopsy in head and neck malignancies: prospective randomized clinical trial to compare ICG-(99m)Tc-nanocolloid hybrid tracer versus (99m)Tc-nanocolloid.European journal of nuclear medicine and molecular imaging · 2015Trial
- Dual-wavelength photoacoustic imaging of sentinel lymph nodes in patients with melanoma and breast cancer.Photoacoustics · 2025Article
- Review
- The Use of Indocyanine Green and Near-Infrared Fluorescence Imaging Versus Blue Dye in Sentinel Lymph Node Biopsy in Cutaneous Melanoma: A Retrospective, Cohort Study.Annals of surgical oncology · 2023Article
- Article
- Article
- Assessment of Nonradioactive Multispectral Optoacoustic Tomographic Imaging With Conventional Lymphoscintigraphic Imaging for Sentinel Lymph Node Biopsy in Melanoma.JAMA network open · 2019Article
- Near-Infrared Dye-Labeled Anti-Prostate Stem Cell Antigen Minibody Enables Real-Time Fluorescence Imaging and Targeted Surgery in Translational Mouse Models.Clinical cancer research : an official journal of the American Association for Cancer Research · 2019Article
- Melanoma & nuclear medicine: new insights & advances.Melanoma management · 2018Review
- Observational
- Indocyanine green detects sentinel lymph nodes in early breast cancer.The Journal of international medical research · 2017Article
- Frequency of level II and III axillary nodes metastases in patients with positive sentinel lymph nodes in melanoma: a multi-institutional study in Japan.International journal of clinical oncology · 2016Article
- A review of performance of near-infrared fluorescence imaging devices used in clinical studies.The British journal of radiology · 2015Review
- Intraoperative imaging-guided cancer surgery: from current fluorescence molecular imaging methods to future multi-modality imaging technology.Theranostics · 2014Review
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAlthough several reports have discussed the potential of the indocyanine green (ICG) fluorescence technique, its effectiveness and limitations have not been fully evaluated. For the accurate detection of sentinel lymph node (SLN) in cutaneous melanoma, which can arise in a wide variety of sites throughout the body, it is important to detect the SLN sites prior to skin incision. The purpose of this study was to evaluate the ICG fluorescence technique in the preoperative setting. PATIENTS AND
methodsWe classified the detection process of SLN biopsy into three surgical stages: 'before skin incision,' 'after skin incision,' and 'ex vivo.' We retrospectively reviewed 93 node fields in 86 patients who underwent SLN biopsies using ICG and conventional techniques.
resultsThe detection rate using ICG at the 'before skin incision,' 'after skin incision,' and 'ex vivo' surgical stages were 63.4, 98.9, and 100 %, respectively. At the 'before skin incision' surgical stage, while lymphoscintigraphy (but not ICG) detected 33 node fields, ICG (but not lymphoscintigraphy) detected only four node fields. The detection rates varied from 100 % in the groin region drained from trunk to 15.8 % in the axillary region from upper limb. The factors that influenced the failure of ICG to identify hot SLNs were an axillary node field (p < 0.001) and a high body mass index (BMI) (p = 0.046).
conclusionFor reliable identification of SLNs in cutaneous melanoma, the ICG fluorescence technique may offer little benefit for patients with axillary node field drained from upper limb, or high BMI.
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