Trial reportCancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology2013
Prevalence and healthcare actions of women in a large health system with a family history meeting the 2005 USPSTF recommendation for BRCA genetic counseling referral.
Trial report in Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers, 1 of them a synthesis that pooled it.
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Who cites it
43 citing papers in PubMed, 1 synthesis or guideline pooled it, 58 citations in OpenAlex.
- Primary care providers' cancer genetic testing-related knowledge, attitudes, and communication behaviors: A systematic review and research agenda.Journal of general internal medicine · 2017Pooled it
- Patient and Clinician Decision Support to Increase Genetic Counseling for Hereditary Breast and Ovarian Cancer Syndrome in Primary Care: A Cluster Randomized Clinical Trial.JAMA network open · 2022Trial
- The use of heuristics in genetic testing decision-making: A qualitative interview study.PloS one · 2021Trial
- Study protocol: a cluster randomized controlled trial of web-based decision support tools for increasing BRCA1/2 genetic counseling referral in primary care.BMC health services research · 2018Trial
- Increasing confidence and changing behaviors in primary care providers engaged in genetic counselling.BMC medical education · 2017Trial
- Impact of a randomized controlled educational trial to improve physician practice behaviors around screening for inherited breast cancer.Journal of general internal medicine · 2015Trial
- Accuracy of ovarian and colon cancer risk assessments by U.S. physicians.Journal of general internal medicine · 2014Trial
- Scoping review of Australian prioritisation frameworks impacting consumer access to clinical genetics: protocol.BMJ open · 2026Article
- Improving genetics equity: identifying women eligible for genetic care services using mammography clinics in underserved areas as screening hubs.The oncologist · 2025Article
- The breast cancer genetic testing experience: probing the potential utility of an online decision aid in risk perception and decision making.BMC cancer · 2025Article
- Diagnostic yield of genetic screening in a diverse, community-ascertained cohort.Genome medicine · 2023Article
- Pharmacogenetic screening in a knowledge-based economy: shouldn't more be better?Annals of translational medicine · 2022Article
- Development and initial testing of a multi-stakeholder intervention for Lynch syndrome cascade screening: an intervention mapping approach.BMC health services research · 2022Article
- An overview of genetic services delivery for hereditary breast cancer.Breast cancer research and treatment · 2022Review
- Financial constraints on genetic counseling and further risk-management decisions among U.S. women at elevated breast cancer risk.Journal of genetic counseling · 2021Article
- Knowledge and perceptions of BRCA1/2 genetic testing and needs of diverse women with a personal or family history of breast cancer in South Florida.Journal of community genetics · 2021Article
- Factors Influencing Discussion of Cancer Genetic Testing with Health-Care Providers in a Population-Based Survey.Public health genomics · 2021Article
- Disparities in BRCA counseling across providers in a diverse population of young breast cancer survivors.Genetics in medicine : official journal of the American College of Medical Genetics · 2020Article
- Mainstreamed genetic testing of breast cancer patients in two hospitals in South Eastern Norway.Familial cancer · 2020Article
- Patients' willingness to reconsider cancer genetic testing after initially declining: Mention it again.Journal of genetic counseling · 2020Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundIn 2005, the United States Preventive Services Task Force (USPSTF) released guidelines which outlined specific family history patterns associated with an increased risk for BRCA1/2 mutations, and recommended at-risk individuals be referred for genetic counseling and evaluation for BRCA testing. The purpose of this study was to assess the prevalence of individuals with a USPSTF increased-risk family history pattern, the frequency with which specific patterns were met, and resulting healthcare actions among women from the Henry Ford Health System.
methodsAs part of a study evaluating ovarian cancer risk perception and screening, 2,524 randomly selected participants completed a detailed interview (response rate 76%) from an initial eligible cohort of 16,720 women.
resultsApproximately 6% of participants had a family history fulfilling one or more of the USPSTF patterns. Although 90% of these women had shared their family history with their provider, less than 20% had been referred for genetic counseling and only 8% had undergone genetic testing. Caucasian women with higher income and education levels were more likely to receive referrals. Among the 95 participants in the total study cohort who reported BRCA testing, 78% did not have a family history that met one of the USPSTF patterns.
conclusionsThese results suggest a higher prevalence of women with an increased-risk family history than originally predicted by the USPSTF, and lack of provider recognition and referral for genetic services. IMPACT: Improvements in healthcare infrastructure and clinician education will be required to realize population level benefits from BRCA genetic counseling and testing.
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