ArticleGastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association2013
Increased levels of SLP-2 correlate with poor prognosis in gastric cancer.
Article in Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 2 of them syntheses that pooled it.
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Who cites it
20 citing papers in PubMed, 2 syntheses or guidelines pooled it, 30 citations in OpenAlex.
- Pooled it
- The diagnostic value of monoclonal gastric cancer 7 antigen: a systematic review with meta-analysis.Clinical and experimental medicine · 2014Pooled it
- STOML2 interacts with PHB to activate the MEK/ERK signaling pathway and mediates autophagy‑related proteins in the progression of hepatocellular carcinoma.International journal of molecular medicine · 2026Article
- STOML2 interacts with PHB through activating MAPK signaling pathway to promote colorectal Cancer proliferation.Journal of experimental & clinical cancer research : CR · 2021Article
- Effect and mechanism of action of SLP-2 on the apoptosis and autophagy of gastric cancer cells.Oncology letters · 2021Article
- Stomatin‑like protein 2 induces metastasis by regulating the expression of a rate‑limiting enzyme of the hexosamine biosynthetic pathway in pancreatic cancer.Oncology reports · 2021Article
- Stomatin-like Protein 2 Promotes Tumor Cell Survival by Activating the JAK2-STAT3-PIM1 Pathway, Suggesting a Novel Therapy in CRC.Molecular therapy oncolytics · 2020Article
- STOML2 as a novel prognostic biomarker modulates cell proliferation, motility and chemo-sensitivity via IL6-Stat3 pathway in head and neck squamous cell carcinoma.American journal of translational research · 2019Article
- Silence of Stomatin-Like Protein 2 Represses Migration and Invasion Ability of Human Liver Cancer Cells via Inhibiting the Nuclear Factor Kappa B (NF-κB) Pathway.Medical science monitor : international medical journal of experimental and clinical research · 2018Article
- Effects of downregulated expression of microRNA-187 in gastric cancer.Experimental and therapeutic medicine · 2018Article
- Stomatin-like protein 2 inhibits cisplatin-induced apoptosis through MEK/ERK signaling and the mitochondrial apoptosis pathway in cervical cancer cells.Cancer science · 2018Article
- A Positive Feedback Loop of SLP2 Activates MAPK Signaling Pathway to Promote Gastric Cancer Progression.Theranostics · 2018Article
- Clinical significance of SLP-2 in hepatocellular carcinoma tissues and its regulation in cancer cell proliferation, migration, and EMT.OncoTargets and therapy · 2017Article
- Integrated miRNA-risk gene-pathway pair network analysis provides prognostic biomarkers for gastric cancer.OncoTargets and therapy · 2016Article
- Stomatin-like protein 2 is overexpressed in epithelial ovarian cancer and predicts poor patient survival.BMC cancer · 2015Article
- WWP1 as a potential tumor oncogene regulates PTEN-Akt signaling pathway in human gastric carcinoma.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2015Article
- Stomatin-like protein 2 expression is associated with clinical survival in patients with cervical cancer.International journal of clinical and experimental pathology · 2015Article
- Overexpression of the Receptor for Advanced Glycation Endproducts (RAGE) is associated with poor prognosis in gastric cancer.PloS one · 2015Article
- Novel findings about management of gastric cancer: a summary from 10th IGCC.World journal of gastroenterology · 2014Article
- Clinicopathological significance of SLP-2 overexpression in human gallbladder cancer.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2014Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundStomatin-like protein 2 (SLP-2) is a member of the highly conserved stomatin protein family whose homologues span from Archaea to humans and include stomatin, SLP-1, and SLP-3. Several studies have indicated that overexpression of SLP-2 is strongly associated with adhesion and migration in several human cancers. The aim of the present study was to evaluate SLP-2 expression at the mRNA and protein level in patients with gastric cancer (GC) and to examine the relationships between SLP-2 expression, clinicopathological features, and prognosis.
methodsWe investigated SLP-2 expression in primary GC and paired normal gastric tissue by real-time PCR (RT-PCR; n = 16) and Western blot analysis (n = 32). Additionally, we performed immunohistochemistry (IHC) on 113 paraffin-embedded GC specimens, 30 matched normal specimens, and 30 paired metastatic lymph node samples.
resultsSLP-2 is overexpressed in GC compared with the adjacent normal gastric epithelium (p < 0.001), and high-level SLP-2 expression is significantly correlated with the depth of invasion, lymph node metastasis, distant metastasis, and American Joint Committee on Cancer (AJCC) stage. Furthermore, elevated SLP-2 expression is an independent prognostic factor in multivariate analysis using the Cox regression model (p = 0.005).
conclusionsOverexpression of SLP-2 may contribute to the progression and poor prognosis of GC.
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