ArticleImmunogenetics2013
Allelic variants in TLR10 gene may influence bilateral affectation and clinical course of Meniere's disease.
Article in Immunogenetics, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers, 3 of them syntheses that pooled it.
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Who cites it
42 citing papers in PubMed, 3 syntheses or guidelines pooled it, 71 citations in OpenAlex.
- Inflammatory and immune pathways in Ménière's disease: a multi-database bibliometric and visualized analysis of research trends.Frontiers in cellular and infection microbiology · 2026Pooled it
- Cataloging Existing Hearing Loss Cohort Data to Guide the Development of Precision Medicine for Sensorineural Hearing Loss: A Systematic Review of Hearing Repositories.The journal of international advanced otology · 2023Pooled it
- Identification of Potential Meniere's Disease Targets in the Adult Stria Vascularis.Frontiers in neurology · 2021Pooled it
- Nutritional Mushroom Treatment in Meniere's Disease withInternational journal of molecular sciences · 2019Trial
- Association of Bilateral Vestibulopathy With theNeurology. Genetics · 2026Article
- Research progress on the mechanisms and animal models of Ménière's disease.Genes & diseases · 2026Review
- Modern Perspectives on the Mechanisms and Non-Genetic Factors in Ménière's Disease-A Narrative Review.Biomedicines · 2026Review
- The Impact of Genetic Factors in Ménière's Disease.International journal of molecular sciences · 2026Review
- Burden of novel and ultra-rare missense variants in the NF-κB pathway genes associated to Ménière's disease.Frontiers in immunology · 2026Article
- Correlation between NLRP6 inflammasome and the levels of inflammatory cytokines IL-1b and IL-18 in serum of patients with Meniere's disease.Journal of medical biochemistry · 2025Article
- Updates on Toll-Like Receptor 10 Research.European journal of immunology · 2025Review
- Comparative analysis of classic and delayed Ménière's disease: clinical characteristics and endolymphatic hydrops manifestations in an Asian cohort.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2025Article
- Immunological mechanisms in Meniere's disease.Frontiers in immunology · 2025Review
- Redox Modulation of Meniere Disease byCurrent neuropharmacology · 2024Article
- Changes in symptom pattern in Meniere's disease by duration: the need for comprehensive management.Frontiers in neurology · 2024Article
- Genetic advances in Meniere Disease.Molecular biology reports · 2023Review
- Ménière's Disease: Insights from an Italian Nationwide Survey.Audiology research · 2023Article
- Human blood-labyrinth barrier model to study the effects of cytokines and inflammation.Frontiers in molecular neuroscience · 2023Article
- Hearing Benefits of Clinical Management for Meniere's Disease.Journal of clinical medicine · 2022Article
- Cytokines and Inflammation in Meniere Disease.Clinical and experimental otorhinolaryngology · 2022Review
Corrections and comments
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Authors and funding
19 authors at 14 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Toll-like receptors trigger the innate immune response by activating various cell types such us macrophages and lymphocytes. We genotyped SNV of TLR3, TRL7, TLR8 and TLR10 in 863 Spanish and 150 Italian patients with Meniere's disease (MD) and 1,013 controls by using Taqman assays. Real-Time qPCR was used to measure the expression level of TLR10 in peripheral blood leukocytes. The overall dataset showed that the C allele and the CC genotype of rs11096955 in TLR10 gene were more commonly observed in controls than patients (corrected p = 1 × 10(-3), OR = 0.68 [95 % confidence interval, 0.54-0.84] for CC genotype; corrected p = 1.5 × 10(-5), OR = 0.75 [0.66-0.85] for allele C). Moreover, the CC genotype was more frequent in patients with uni- (19 %) than bilateral sensorineural hearing loss (SNHL) (13 %). Logistic regression demonstrated that the time since the onset of MD, Tumarkin crises, hearing stage and rs11096955 were independent factors influencing the risk of bilateral SNHL. In addition, rs11096955 influenced hearing loss progression in patients with bilateral MD. No change in expression of TLR10 was observed according to CC, CA or AA genotypes. Our data suggest that allelic variants of TLR10 gene may influence the susceptibility and time-course of hearing loss of MD in the European population.
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