ArticleWorld journal of surgery2013
Catecholamine dosing and survival in adult intensive care unit patients.
Article in World journal of surgery, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 28 citations in OpenAlex.
- Early multimodal vasopressor strategy in septic shock: results of the TRICYCLE randomized controlled trial.Critical care (London, England) · 2026Trial
- A hybrid multi-criteria decision-making framework for prioritising clinical determinants of medical futility in the intensive care unit.Journal of intensive care · 2026Article
- Pathophysiology and Perioperative Considerations for Heart Failure Patients.Life (Basel, Switzerland) · 2026Review
- Prehospital invasive vs. non-invasive blood pressure monitoring: Impact on shock index at hospital admission in critically ill patients - a prospective intervention study.Scandinavian journal of trauma, resuscitation and emergency medicine · 2025Article
- Trends and outcomes of chemotherapy timing in critically ill patients with hematologic malignancies using a Japanese national database.Scientific reports · 2025Article
- Early multimodal vasopressor strategy in septic shock (TRICYCLE)-Study protocol for a randomized controlled clinical trial.PloS one · 2025Article
- Cardiovascular Magnetic Resonance in Survivors of Critical Illness: Cardiac Abnormalities Are Associated With Acute Kidney Injury.Journal of the American Heart Association · 2023Article
- Inotrope Use and Intensive Care Unit Mortality in Patients With Cardiogenic Shock: An Analysis of a Large Electronic Intensive Care Unit Database.Frontiers in cardiovascular medicine · 2021Article
- Vasopressors in septic shock: which, when, and how much?Annals of translational medicine · 2020Review
- Outcome of patients with septic shock and high-dose vasopressor therapy.Annals of intensive care · 2017Article
- Monitoring of Tissue Oxygenation: an Everyday Clinical Challenge.Frontiers in medicine · 2017Review
- Effects of epinephrine on angiogenesis-related gene expressions in cultured rat cardiomyocytes.Journal of biomedical research · 2016Article
- Should the norepinephrine maximal dosage rate be greatly increased in late shock?BMJ case reports · 2016Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundVolume management and vasopressor support remain the gold standard of critical care for patients with shock. However, prolonged therapy with catecholamines in high doses is associated with a negative patient outcome. The aim of the present study was to analyze the administered levels of catecholamines over time with respect to survival, and to identify a cut-off to allow a prediction of survival.
methodsConsecutively, 9,108 adult patients during 22 months were evaluated. This group included 1,543 patients treated with epinephrine and/or norepinephrine with any dose at any time. Time and dosages of the applied drugs, the sequential organ failure assessment and acute and chronic health evaluation II scores on admission and daily, the length of intensive care unit stay, and the outcomes were recorded.
resultsThe non-survivors received higher doses of norepinephrine and epinephrine than the survivors (p < 0.001). The receiver operator characteristic curve for the area under the curve with non-survival as the classifier revealed a cut-off level of 294.33 μg/kg for norepinephrine with a sensitivity of 74.73 % and a specificity of 70.48 % and a cut-off for epinephrine of 70.36 μg/kg with a sensitivity of 83.87 % and a specificity of 72.79 %. Dose-dependent time curves using these cut-off values were calculated.
conclusionsSurvival of patients with prolonged therapy with norepinephrine and epinephrine above the evaluated thresholds is poor, whereas short-term application of high-dose catecholamines is not associated with poor outcome. Therefore, it remains for the individual clinician, patients, and their surrogates to decide whether the use of high doses of vasopressors is appropriate in view of the low probability of survival.
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