ReviewHearing research2013
Prospects for replacement of auditory neurons by stem cells.
Review in Hearing research, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07472023 (Truway Health Inner Ear Regeneration & Hearing Restoration Trial), which is not on this map. Cited by 26 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Truway Health Inner Ear Regeneration & Hearing Restoration Trial
Who cites it
26 citing papers in PubMed, 47 citations in OpenAlex.
- Study on Recovery Strategy of Hearing Loss & SGN Regeneration Under Physical Regulation.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Review
- A novel minimally invasive stereotaxic technique to target inner ear neurons in the mouse.Frontiers in neurology · 2025Article
- Schwann cells in the inner ear: development, disease, and regeneration.Frontiers in cellular neuroscience · 2025Review
- Growth factors with valproic acid restore injury-impaired hearing by promoting neuronal regeneration.JCI insight · 2021Article
- Ceramide Kinase Inhibition Blocks IGF-1-Mediated Survival of Otic Neurosensory Progenitors by Impairing AKT Phosphorylation.Frontiers in cell and developmental biology · 2021Article
- Stem Cell-Based Therapies in Hearing Loss.Frontiers in cell and developmental biology · 2021Review
- Molecular Aspects of the Development and Function of Auditory Neurons.International journal of molecular sciences · 2020Review
- Lin28 reprograms inner ear glia to a neuronal fate.Stem cells (Dayton, Ohio) · 2020Article
- Imaging Bioluminescent Exogenous Stem Cells in the Intact Guinea Pig Cochlea.Anatomical record (Hoboken, N.J. : 2007) · 2020Article
- Increased levels of miR-124 in human dental pulp stem cells alter the expression of neural markers.Journal of otology · 2019Article
- Single-Cell Fluorescence Analysis of Pseudotemporal Ordered Cells Provides Protein Expression Dynamics for Neuronal Differentiation.Frontiers in cell and developmental biology · 2019Article
- Organotypic Cocultures of Human Pluripotent Stem Cell Derived-Neurons with Mammalian Inner Ear Hair Cells and Cochlear Nucleus Slices.Stem cells international · 2019Article
- The Presence of Neural Stem Cells and Changes in Stem Cell-Like Activity With Age in Mouse Spiral Ganglion Cells In Vivo and In Vitro.Clinical and experimental otorhinolaryngology · 2018Article
- Potential Application of Electrical Stimulation in Stem Cell-Based Treatment against Hearing Loss.Neural plasticity · 2018Review
- A Protocol for Decellularizing Mouse Cochleae for Inner Ear Tissue Engineering.Journal of visualized experiments : JoVE · 2018Article
- NEUROG1 Regulates CDK2 to Promote Proliferation in Otic Progenitors.Stem cell reports · 2017Article
- Concomitant differentiation of a population of mouse embryonic stem cells into neuron-like cells and schwann cell-like cells in a slow-flow microfluidic device.Developmental dynamics : an official publication of the American Association of Anatomists · 2017Article
- No longer falling on deaf ears: mechanisms of degeneration and regeneration of cochlear ribbon synapses.Hearing research · 2015Review
- Importance of cochlear health for implant function.Hearing research · 2015Review
- Genome-wide demethylation by 5-aza-2'-deoxycytidine alters the cell fate of stem/progenitor cells.Stem cell reviews and reports · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
Sensorineural hearing loss is caused by degeneration of hair cells or auditory neurons. Spiral ganglion cells, the primary afferent neurons of the auditory system, are patterned during development and send out projections to hair cells and to the brainstem under the control of largely unknown guidance molecules. The neurons do not regenerate after loss and even damage to their projections tends to be permanent. The genesis of spiral ganglion neurons and their synapses forms a basis for regenerative approaches. In this review we critically present the current experimental findings on auditory neuron replacement. We discuss the latest advances with a focus on (a) exogenous stem cell transplantation into the cochlea for neural replacement, (b) expression of local guidance signals in the cochlea after loss of auditory neurons, (c) the possibility of neural replacement from an endogenous cell source, and (d) functional changes from cell engraftment.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.