Evidence map›Paper›PMID 23370206›Full record

ArticleBritish journal of cancer2013

Diabetes mellitus and risk of hepatocellular carcinoma: findings from the Singapore Chinese Health Study.

W-P Koh, R Wang, A Jin, M C Yu, J-M Yuan

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in British journal of cancer, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 60 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
60citing papers in PubMed, 3 pooled it
4.7field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

60 citing papers in PubMed, 3 syntheses or guidelines pooled it, 89 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Trial
  5. Review
  6. Review
  7. Article
  8. Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Review
  15. Review
  16. Article
  17. Review
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 2 countries.

W-P KohDuke-NUS Graduate Medical School Singapore, Singapore.
R Wang
A Jin
M C Yu
J-M Yuan
UPMC Hillman Cancer Center · USDuke-NUS Medical School · SGMinistry of Health · SGUniversity of Southern California · US

Funding

Prospective studies of cancer etiology and prevention in Shanghai and SingaporeR01CA144034 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI YUAN, JIAN-MIN · 2010 to 2014
$7.0M
THE SINGAPORE COHORT STUDY OF DIET AND CANCERR01CA080205 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI YUAN, JIAN-MIN · 1999 to 2009
$5.3M
COHORT STUDY OF DIET AND NASOPHYARYNGEAL CANCERR01CA055069 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI YU, MIMI C. · 1992 to 1992
–
ENVIRONMENTAL EXPOSURES IN CANCER ETIOLOGYR35CA053890 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI YU, MIMI C. · 1992 to 1998
–
NCI NIH HHS R01 CA055069NCI NIH HHS R01 CA080205NCI NIH HHS R01 CA144034NCI NIH HHS R01 CA80205NCI NIH HHS R35 CA053890
6 · The paper itself

Abstract

backgroundThe increasing prevalence of diabetes may contribute to the rising incidence of hepatocellular carcinoma (HCC) in the US and other developed countries where HCC incidence is relatively low. Data from prospective studies on diabetes and risk of HCC in at-risk populations due to high prevalence of viral hepatitis in southeast Asia are sparse.

methodsThe Singapore Chinese Health Study is a prospective cohort of 63, 257 middle-aged and older Chinese men and women enrolled in 1993-1998. Besides an in-person interview administered to all participants at baseline, testing of serologic markers of hepatitis B or C infections were performed on a subset of cohort subjects. After a mean follow-up of 14 years, 499 cohort participants developed HCC.

resultsA history of diabetes at baseline was associated with a hazard ratio of 2.14 (95% confidence interval, 1.69-2.71). This statistically significant association was comparable in magnitude between men and women, and remained equally strong across strata of subjects defined by the number of years between their first clinical diagnosis of diabetes and time of enrollment in this cohort. Within a nested case-control set of cohort subjects tested for serological markers of hepatitis B or C infections, the diabetes-HCC association was found to be present mainly among those devoid of any markers.

conclusionA history of diabetes at baseline is highly associated with non-viral HCC. Future studies are warranted to elucidate the biological mechanism underpinning the role of diabetes in nonviral-related hepatocarcinogenesis.

Indexed as

Asian PeopleCarcinoma, HepatocellularCohort StudiesDiabetes MellitusFemaleHepatitis BHepatitis C, ChronicHumansLiver NeoplasmsMaleMiddle AgedProspective StudiesRiskSingapore

Identifiers

PMID23370206
PMCPMC3619062
OpenAlexW2039991409

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.