ReviewMolecular and cellular endocrinology2013
Nonhuman primate models of polycystic ovary syndrome.
Review in Molecular and cellular endocrinology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 58 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
58 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Androgen levels in the fetal cord blood of children born to women with polycystic ovary syndrome: a meta-analysis.Reproductive biology and endocrinology : RB&E · 2020Pooled it
- The Stimulating Effect of Low-Molecular-Weight Luteinizing Hormone Receptor Agonist on Steroidogenesis and Ovulation in Female Rats with Dehydroepiandrosterone-Induced Polycystic Ovary Syndrome.International journal of molecular sciences · 2026Article
- A challenging hypothesis: can a SNP changing cysteine 1 in the α inhibin pro-domain induce reproduction-linked PCOS phenotypes?Frontiers in endocrinology · 2026Review
- Neuroendocrine mechanisms responsible for elevated gonadotrophin-releasing hormone and luteinising hormone pulses in polycystic ovary syndrome.Journal of neuroendocrinology · 2025Review
- Murine Models and Human Cell Line Models to Study Altered Dynamics of Ovarian Follicles in Polycystic Ovary Syndrome.Advanced biology · 2025Review
- Endocrine disrupting chemicals and the adrenal gland.Turkish journal of medical sciences · 2025Review
- Targeted inhibition of kisspeptin neurons reverses hyperandrogenemia and abnormal hyperactive LH secretion in a preclinical mouse model of polycystic ovary syndrome.Human reproduction (Oxford, England) · 2024Article
- Developmental programming: Testosterone excess masculinizes female pancreatic transcriptome and function in sheep.Molecular and cellular endocrinology · 2024Article
- Effect of maternal polycystic ovary syndrome (PCOS) on screening of aneuploidy in the first and second trimesters.Journal of ovarian research · 2023Article
- Non-human primate models for understanding the impact of the microbiome on pregnancy and the female reproductive tract†.Biology of reproduction · 2023Review
- Differential Strain-dependent Ovarian and Metabolic Responses in a Mouse Model of PCOS.Endocrinology · 2023Article
- Review
- Central Regulation of PCOS: Abnormal Neuronal-Reproductive-Metabolic Circuits in PCOS Pathophysiology.Frontiers in endocrinology · 2021Review
- Inhibition ofFrontiers in cell and developmental biology · 2021Article
- Resistance to the Insulin and Elevated Level of Androgen: A Major Cause of Polycystic Ovary Syndrome.Frontiers in endocrinology · 2021Review
- Early pregnancy maternal progesterone administration alters pituitary and testis function and steroid profile in male fetuses.Scientific reports · 2020Article
- Firing patterns of gonadotropin-releasing hormone neurons are sculpted by their biologic state.Royal Society open science · 2020Article
- Insights into Manipulating Postprandial Energy Expenditure to Manage Weight Gain in Polycystic Ovary Syndrome.iScience · 2020Article
- Generation of cynomolgus monkey fetuses with intracytoplasmic sperm injection based on the MII-stage oocytes acquired by personalized superovulation protocol.Journal of veterinary science · 2020Article
- The Correlation between Hormonal Disturbance in PCOS Women and Serum Level of Kisspeptin.International journal of endocrinology · 2020Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
With close genomic and phenotypic similarity to humans, nonhuman primate models provide comprehensive epigenetic mimics of polycystic ovary syndrome (PCOS), suggesting early life targeting for prevention. Fetal exposure to testosterone (T), of all nonhuman primate emulations, provides the closest PCOS-like phenotypes, with early-to-mid gestation T-exposed female rhesus monkeys exhibiting adult reproductive, endocrinological and metabolic dysfunctional traits that are co-pathologies of PCOS. Late gestational T exposure, while inducing adult ovarian hyperandrogenism and menstrual abnormalities, has less dysfunctional metabolic accompaniment. Fetal exposures to dihydrotestosterone (DHT) or diethylstilbestrol (DES) suggest androgenic and estrogenic aspects of fetal programming. Neonatal exposure to T produces no PCOS-like outcome, while continuous T treatment of juvenile females causes precocious weight gain and early menarche (high T), or high LH and weight gain (moderate T). Acute T exposure of adult females generates polyfollicular ovaries, while chronic T exposure induces subtle menstrual irregularities without metabolic dysfunction.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.