ArticleNeurobiology of aging2013
Multiple clinically relevant hormone therapy regimens fail to improve cognitive function in aged ovariectomized rhesus monkeys.
Article in Neurobiology of aging, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
16 citing papers in PubMed, 31 citations in OpenAlex.
- The aged female rhesus macaque as a translational model for human menopause and hormone therapy.Hormones and behavior · 2024Article
- Interest in non-social novel stimuli as a function of age in rhesus monkeys.Royal Society open science · 2019Article
- The Role of Estrogen in Brain and Cognitive Aging.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2019Review
- Estradiol treatment in a nonhuman primate model of menopause preserves affective reactivity.Behavioral neuroscience · 2018Article
- Timing of cyclic estradiol treatment differentially affects cognition in aged female rhesus monkeys.Behavioral neuroscience · 2018Article
- Translational Significance of Selective Estrogen Receptor Modulators in Psychiatric Disorders.International journal of endocrinology · 2018Review
- Socially Housed Female Macaques: a Translational Model for the Interaction of Chronic Stress and Estrogen in Aging.Current psychiatry reports · 2017Review
- Cognition in aged rhesus monkeys: effect of DHEA and correlation with steroidogenic gene expression.Genes, brain, and behavior · 2017Article
- Evaluating the Role of Hormone Therapy in Postmenopausal Women with Alzheimer's Disease.Drugs & aging · 2016Review
- Effect of Ovarian Hormone Therapy on Cognition in the Aged Female Rhesus Macaque.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
- Age and Long-Term Hormone Treatment Effects on the Ultrastructural Morphology of the Median Eminence of Female Rhesus Macaques.Neuroendocrinology · 2016Article
- Postmenopausal hormone therapy and cognition.Hormones and behavior · 2015Review
- Estrogen Effects on Cognitive and Synaptic Health Over the Lifecourse.Physiological reviews · 2015Review
- Oestradiol modulation of cognition in adult female marmosets (Callithrix jacchus).Journal of neuroendocrinology · 2014Article
- GnRH neurons of young and aged female rhesus monkeys co-express GPER but are unaffected by long-term hormone replacement.Neuroendocrinology · 2014Article
- Sex hormones selectively impact the endocervical mucosal microenvironment: implications for HIV transmission.PloS one · 2014Article
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 1 country.
Funding
Abstract
Preclinical studies in aged, surgically-menopausal rhesus monkeys have revealed powerful benefits of intermittent estrogen injections on prefrontal cortex-dependent working memory, together with corresponding effects on dendritic spine morphology in the prefrontal cortex. This contrasts with the inconsistent effects of hormone therapy (HT) reported in clinical studies in women. Factors contributing to this discrepancy could include differences in the formulation and sequence of HT regimens, resulting in different neurobiological outcomes. The current study evaluated, in aging surgically menopausal rhesus monkeys, the cognitive effects of 4 HT regimens modeled directly on human clinical practice, including continuous estrogen treatment opposed by progesterone. None of the regimens tested produced any cognitive effect, despite yielding physiologically relevant serum hormone levels, as intended. These findings have implications for the design of regimens that might optimize the benefits of hormone treatment for healthy aging, and suggest that common HT protocols used by women may fail to result in substantial cognitive benefit, at least via direct effects on the prefrontal cortex.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.