ArticleTransplantation research2012
A simplified subnormothermic machine perfusion system restores ischemically damaged liver grafts in a rat model of orthotopic liver transplantation.
Article in Transplantation research, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers.
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Who cites it
51 citing papers in PubMed.
- Article
- Development of a Swine Whole Eye Transplant Ex Vivo Perfusion Protocol.Artificial organs · 2026Article
- Cellular and Molecular Changes Induced by Various Preservation Temperatures and Methods of Preservation in Renal Grafts and Other Solid Organ Grafts.International journal of molecular sciences · 2026Review
- Therapeutic priming of liver regeneration: from mechanisms toFrontiers in transplantation · 2026Review
- Development of a 24-h Preservation Protocol of Forearm Vascularized Composite Allotransplants in Nonhuman Primates Using Subnormothermic Machine Perfusion.Transplantation direct · 2025Article
- Ex vivo machine perfusion as a platform for lentiviral gene delivery in rat livers.Gene therapy · 2025Article
- Beyond the icebox: modern strategies in organ preservation for transplantation.Clinical transplantation and research · 2024Review
- Endothelial Cells and Mitochondria: Two Key Players in Liver Transplantation.International journal of molecular sciences · 2023Review
- Exceeding the Limits of Static Cold Storage in Limb Transplantation Using Subnormothermic Machine Perfusion.Journal of reconstructive microsurgery · 2023Article
- Current practice and novel approaches in organ preservation.Frontiers in transplantation · 2023Review
- The Role of IGL-2 Preservation Solution on Rat Livers during SCS and HOPE.International journal of molecular sciences · 2022Article
- Partial freezing of rat livers extends preservation time by 5-fold.Nature communications · 2022Article
- Optimization of Ex Vivo Machine Perfusion and Transplantation of Vascularized Composite Allografts.The Journal of surgical research · 2022Article
- Optimal Temperature Protocols for Liver Machine Perfusion Using a Monte Carlo Method.IFAC-PapersOnLine · 2022Article
- Human liver stem cell-derived extracellular vesicles reduce injury in a model of normothermic machine perfusion of rat livers previously exposed to a prolonged warm ischemia.Transplant international : official journal of the European Society for Organ Transplantation · 2021Article
- Advanced technologies for the preservation of mammalian biospecimens.Nature biomedical engineering · 2021Review
- Cell release during perfusion reflects cold ischemic injury in rat livers.Scientific reports · 2020Article
- Split-Liver Ex Situ Machine Perfusion: A Novel Technique for Studying Organ Preservation and Therapeutic Interventions.Journal of clinical medicine · 2020Article
- Subnormothermic Machine Perfusion of Steatotic Livers Results in Increased Energy Charge at the Cost of Anti-Oxidant Capacity Compared to Normothermic Perfusion.Metabolites · 2019Article
- The Effect of Preservation Temperature on Liver, Kidney, and Pancreas Tissue ATP in Animal and Preclinical Human Models.Journal of clinical medicine · 2019Review
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
unlabelled
backgroundLiver donor shortages stimulate the development of strategies that incorporate damaged organs into the donor pool. Herein we present a simplified machine perfusion system without the need for oxygen carriers or temperature control, which we validated in a model of orthotopic liver transplantation.
methodsRat livers were procured and subnormothermically perfused with supplemented Williams E medium for 3 hours, then transplanted into healthy recipients (Fresh-SNMP group). Outcome was compared with static cold stored organs (UW-Control group). In addition, a rat liver model of donation after cardiac death was adapted using a 60-minute warm ischemic period, after which the grafts were either transplanted directly (WI group) or subnormothermically perfused and transplanted (WI-SNMP group).
resultsOne-month survival was 100% in the Fresh-SNMP and UW-Control groups, 83.3% in the WI-SNMP group and 0% in the WI group. Clinical parameters, postoperative blood work and histology did not differ significantly between survivors.
conclusionThis work demonstrates for the first time in an orthotopic transplantation model that ischemically damaged livers can be regenerated effectively using practical subnormothermic machine perfusion without oxygen carriers.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.