ArticleMedical gas research2013
XENON in medical area: emphasis on neuroprotection in hypoxia and anesthesia.
Article in Medical gas research, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Inhalational Gases for Neuroprotection in Traumatic Brain Injury.Journal of neurotrauma · 2021Pooled it
- Xenon gas as a potential treatment for opioid use disorder, alcohol use disorder, and related disorders.Medical gas research · 2025Review
- Exploration of Cryptic Pockets Using Enhanced Sampling Along Normal Modes: A Case Study of KRASJournal of chemical information and modeling · 2024Article
- Article
- Advances in Therapies to Treat Neonatal Hypoxic-Ischemic Encephalopathy.Journal of clinical medicine · 2023Review
- Beta-Site Amyloid Precursor Protein-Cleaving Enzyme Inhibition Partly Restores Sevoflurane-Induced Deficits on Synaptic Plasticity and Spine Loss.International journal of molecular sciences · 2022Article
- Multivariable Dependence of Acoustic Contrast of Fluorocarbon and Xenon Microbubbles under Flow.Ultrasound in medicine & biology · 2021Article
- Peculiarities of Thermodynamic Behaviors of Xenon Adsorption on the Activated Carbon Prepared from Silicon Carbide.Nanomaterials (Basel, Switzerland) · 2021Article
- Radical pairs may play a role in xenon-induced general anesthesia.Scientific reports · 2021Article
- Ultrasound Responsive Noble Gas Microbubbles for Applications in Image-Guided Gas Delivery.Advanced healthcare materials · 2020Article
- Neuroprotection of dopamine neurons by xenon against low-level excitotoxic insults is not reproduced by other noble gases.Journal of neural transmission (Vienna, Austria : 1996) · 2020Article
- Better haemodynamic stability under xenon anaesthesia than under isoflurane anaesthesia during partial nephrectomy - a secondary analysis of a randomised controlled trial.BMC anesthesiology · 2019Article
- Inhaled Gases for Neuroprotection of Neonates: A Review.Frontiers in pediatrics · 2019Review
- Delivery of xenon-containing echogenic liposomes inhibits early brain injury following subarachnoid hemorrhage.Scientific reports · 2018Article
- Xenon-Protein Interactions: Characterization by X-Ray Crystallography and Hyper-CEST NMR.Methods in enzymology · 2018Article
- The elements of life and medicines.Philosophical transactions. Series A, Mathematical, physical, and engineering sciences · 2015Article
- Pharmacokinetic analysis of the chronic administration of the inert gases Xe and Ar using a physiological based model.Medical gas research · 2015Article
- Anti-oxidative aspect of inhaled anesthetic gases against acute brain injury.Medical gas researchReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Xenon is a medical gas capable of establishing neuroprotection, inducing anesthesia as well as serving in modern laser technology and nuclear medicine as a contrast agent. In spite of its high cost, its lack of side effects, safe cardiovascular and organoprotective profile and effective neuroprotective role after hypoxic-ischemic injury (HI) favor its applications in clinics. Xenon performs its anesthetic and neuroprotective functions through binding to glycine site of glutamatergic N-methyl-D-aspartate (NMDA) receptor competitively and blocking it. This blockage inhibits the overstimulation of NMDA receptors, thus preventing their following downstream calcium accumulating cascades. Xenon is also used in combination therapies together with hypothermia or sevoflurane. The neuroprotective effects of xenon and hypothermia cooperate synergistically whether they are applied synchronously or asynchronously. Distinguishing properties of Xenon promise for innovations in medical gas field once further studies are fulfilled and Xenon's high cost is overcome.
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.