ArticleCough (London, England)2013
Fentanyl enhances the excitability of rapidly adapting receptors to cause cough via the enhancement of histamine release in the airways.
Article in Cough (London, England), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 2 syntheses or guidelines pooled it, 41 citations in OpenAlex.
- Dezocine prevents sufentanil-induced cough during general anesthesia induction: a meta-analysis of randomised controlled trials.BMC anesthesiology · 2020Pooled it
- Pharmacological and nonpharmacological prevention of fentanyl-induced cough: a meta-analysis.Journal of anesthesia · 2014Pooled it
- Effect of tegileridine pretreatment on fentanyl-induced cough during general anesthesia induction: a randomized controlled trial.Frontiers in medicine · 2026Trial
- Effective Dose of Oliceridine for Inhibiting Hemodynamic Elevation Induced by Tracheal Intubation: An Up-and-Down Sequential Trial.Drug design, development and therapy · 2025Trial
- Low-Dose Alfentanil Inhibits Sufentanil-Induced Cough During Anesthesia Induction: A Prospective, Randomized, Double-Blind Study.Drug design, development and therapy · 2024Trial
- Swallowing action immediately before intravenous fentanyl at induction of anesthesia prevents fentanyl-induced coughing: a randomized controlled study.Journal of anesthesia · 2017Trial
- Trial
- A priming dose of intravenous ketamine-dexmedetomidine suppresses fentanyl-induced coughing: a double-blind, randomized, controlled study.Upsala journal of medical sciences · 2014Trial
- Administration of fentanyl via a slow intravenous fluid line compared with rapid bolus alleviates fentanyl-induced cough during general anesthesia induction.Journal of Zhejiang University. Science. BTrial
- Inclusion of vitexin in β-cyclodextrin: preparation, characterization and expectorant/antitussive activities.Heliyon · 2020Article
- Drug-Induced Cough.Physiological research · 2020Review
- Mechanism and Management of Fentanyl-Induced Cough.Frontiers in pharmacology · 2020Review
- Pretreatment with Nalbuphine Prevents Sufentanil-Induced Cough During the Anesthesia Induction: A Randomized Controlled Trial.Therapeutics and clinical risk management · 2020Article
- Role of pre-emptive Huff's manoeuvre and acupressure in reducing the incidence of fentanyl induced cough; a risk factor for postoperative nausea vomiting in female patients: A prospective randomised controlled study.Indian journal of anaesthesia · 2019Article
- Effect of preoperative incentive spirometry on fentanyl-induced cough: a prospective, randomized, controlled study.Korean journal of anesthesiology · 2017Article
- Dezocine attenuates fentanyl-induced cough in a dose-dependent manner-a randomized controlled trial.International journal of clinical and experimental medicine · 2015Article
- Magnesium sulfate inhibits sufentanil-induced cough during anesthetic induction.International journal of clinical and experimental medicine · 2015Article
- Magnesium sulphate suppresses fentanyl-induced cough during general anesthesia induction: a double-blind, randomized, and placebo-controlled study.International journal of clinical and experimental medicine · 2015Article
- Intravenous lidocaine suppresses fentanyl-induced cough in Children.Cough (London, England) · 2013Article
- Can low dose of propofol effectively suppress fentanyl-induced cough during induction of anaesthesia? A double blind randomized controlled trial.Journal of anaesthesiology, clinical pharmacologyArticle
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
unlabelled
backgroundAlthough the mechanism of fentanyl-induced cough is unclear, several lines of evidence suggest that allergic mediators, such as histamine, may play a role in the production of fentanyl-induced coughs. The aim of this study was to explore the effects of fentanyl on cough sensitivity to inhaled citric acid and on histamine release in BALF in mice.
methodsThe cough reflex was induced by the inhalation of citric acid. Male ICR mice were exposed to a nebulized solution of citric acid at a concentration of 0.1 M under conscious and identical conditions using a body plethysmograph. The number of coughs produced per 3-min period of exposure to citric acid was counted. Histamine content in BALF was analyzed by HPLC post-column derivatization and fluorescence detection.
resultsIntravenous administration of fentanyl increased the number of citric acid-induced coughs. The fentanyl-induced enhancement of the number of citric acid-induced coughs was abolished in mice that had been pretreated with moguisteine, a rapidly adapting receptor (RAR) antagonist or fexofenadine, a histamine H1 receptor antagonist. Fentanyl significantly increased the concentration of histamine in BALF.
conclusionThe results of this study suggest that fentanyl enhances the excitability of RARs to cause cough, and enhancement of histamine release in the airways may some how be related to this change.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.