ArticleBMC pediatrics2013
High incidence of pulmonary tuberculosis in children admitted with severe pneumonia in Uganda.
Article in BMC pediatrics, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
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Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it, 45 citations in OpenAlex.
- A systematic review of clinical, epidemiological and demographic predictors of tuberculosis in children with pneumonia.Journal of global health · 2022Pooled it
- Article
- Paediatric pulmonary disease-are we diagnosing it right?Frontiers in pediatrics · 2024Article
- Tuberculosis diagnostic and treatment delays among patients in Uganda.Health science reports · 2023Article
- Predictors of mortality in Ugandan children with TB, 2016-2021.The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease · 2023Article
- Article
- High burden of pulmonary tuberculosis and missed opportunity to initiate treatment among children in Kampala, Uganda.African health sciences · 2022Article
- Acute Intrathoracic Tuberculosis in Children and Adolescents with Community-Acquired Pneumonia in an Area with an Intermediate Disease Burden.Pediatric reports · 2022Article
- Global, regional, and national sex differences in the global burden of tuberculosis by HIV status, 1990-2019: results from the Global Burden of Disease Study 2019.The Lancet. Infectious diseases · 2022Article
- Article
- Article
- Xpert MTB/RIF assay did not improve diagnosis of pulmonary tuberculosis among child contacts in Rwanda.The Pan African medical journal · 2018Article
- Trend and outcome of notified children with tuberculosis during 2011-2015 in Kampala, Uganda.BMC public health · 2017Article
- Integration of childhood TB into guidelines for the management of acute malnutrition in high burden countries.Public health action · 2017Article
- Child pneumonia - focus on the Western Pacific Region.Paediatric respiratory reviews · 2017Review
- Deaths during tuberculosis treatment among paediatric patients in a large tertiary hospital in Nigeria.PloS one · 2017Article
- Emergency treatment and nursing of children with severe pneumonia complicated by heart failure and respiratory failure: 10 case reports.Experimental and therapeutic medicine · 2016Article
- Study of 9 Cases of Tuberculosis Pneumonia in Children at Chu of Brazzaville, Congo.Global pediatric health · 2016Article
- Importance of tuberculosis control to address child survival.Lancet (London, England) · 2014Article
- Reducing deaths from severe pneumonia in children in Malawi by improving delivery of pneumonia case management.PloS one · 2014Article
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundA high prevalence of tuberculosis (TB) in children presenting with severe pneumonia has previously been reported in South Africa. However, little is known about TB among children with pneumonia in Uganda and other resource limited countries. Moreover, TB is associated with high morbidity and mortality among such children. We conducted this study to establish the burden of pulmonary TB in children admitted with severe pneumonia in our setting.
methodsA cross-sectional study was conducted at Mulago, a National Referral and teaching hospital in Uganda. Hospitalised children 2 months to 12 years of age with severe pneumonia based on WHO case definition were enrolledfrom February to June 2011. Children with a previous TB diagnosis or receiving anti-TB treatment were excluded. Each child was screened for TB using Tuberculin skin test, Chest X-ray, induced sputum samples and blood culture for mycobacterium. Sputum smears were examined using fluorescent microscopy, and cultured on both Lowenstein Jensen media (LJ) and Mycobacterial Growth Indicator Tubes (MGIT).
resultsOf the 270 children with severe pneumonia who were recruited over a 5-month period in 2011, the incidence ratio of pulmonary TB in children admitted with severe pneumonia was 18.9% (95% CI 14.6 - 23.9). The proportion of culture confirmed PTB was 6.3% (95% CI 3.8 - 9.7). Age group under 1 year and 1 to 5 years (OR 2.8 (95% CI 1.7 - 7.4) and OR 2.4 (95% CI 1.05 - 5.9) respectively) were more likely to be associated with pulmonary TB compared to those children over 5 years of age. A history of TB smear positive contact was associated with pulmonary TB (OR 3.0 (95% CI 1.3-6.5).
conclusionsWe found a high burden of pulmonary TB in children admitted with severe pneumonia. These data highlight the need for TB screening in children admitted with severe pneumonia so as to improve TB case finding and child survival.
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