ArticlePloS one2013
Profiling of humoral response to influenza A(H1N1)pdm09 infection and vaccination measured by a protein microarray in persons with and without history of seasonal vaccination.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 48 citations in OpenAlex.
- Trial
- Assessment of pre and postinfection immunity to the hemagglutinin proteins of Influenza A(H1N1)pdm09 and Influenza A(H3N2) in India: a retrospective longitudinal study.Virology journal · 2026Article
- Assessing West Nile virus (WNV) and Usutu virus (USUV) exposure in bird ringers in the Netherlands: a high-risk group for WNV and USUV infection?One health (Amsterdam, Netherlands) · 2023Article
- ADCC: An underappreciated correlate of cross-protection against influenza?Frontiers in immunology · 2023Review
- Different decay of antibody response and VOC sensitivity in naïve and previously infected subjects at 15 weeks following vaccination with BNT162b2.Journal of translational medicine · 2022Article
- Age-seroprevalence curves for the multi-strain structure of influenza A virus.Nature communications · 2021Article
- Accurate serology for SARS-CoV-2 and common human coronaviruses using a multiplex approach.Emerging microbes & infections · 2020Article
- A Complex Dance: Measuring the Multidimensional Worlds of Influenza Virus Evolution and Anti-Influenza Immune Responses.Pathogens (Basel, Switzerland) · 2019Review
- Structure of general-population antibody titer distributions to influenza A virus.Scientific reports · 2017Article
- Different Repeat Annual Influenza Vaccinations Improve the Antibody Response to Drifted Influenza Strains.Scientific reports · 2017Article
- Evaluation of multiplex assay platforms for detection of influenza hemagglutinin subtype specific antibody responses.Journal of virological methods · 2017Article
- Heterosubtypic cross-reactivity of HA1 antibodies to influenza A, with emphasis on nonhuman subtypes (H5N1, H7N7, H9N2).PloS one · 2017Article
- Quantifying homologous and heterologous antibody titre rises after influenza virus infection.Epidemiology and infection · 2016Article
- Preserved antiviral adaptive immunity following polyclonal antibody immunotherapy for severe murine influenza infection.Scientific reports · 2016Article
- Article
- Statistical identifiability and sample size calculations for serial seroepidemiology.Epidemics · 2015Article
- Joint modelling of serological and hospitalization data reveals that high levels of pre-existing immunity and school holidays shaped the influenza A pandemic of 2009 in the Netherlands.Journal of the Royal Society, Interface · 2015Article
- Proteinquakes in the evolution of influenza virus hemagglutinin (A/H1N1) under opposing migration and vaccination pressures.BioMed research international · 2015Article
- Difference in immune response in vaccinated and unvaccinated Swedish individuals after the 2009 influenza pandemic.BMC infectious diseases · 2014Article
- Discrimination of influenza infection (A/2009 H1N1) from prior exposure by antibody protein microarray analysis.PloS one · 2014Article
Corrections and comments
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Authors and funding
12 authors at 6 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe influence of prior seasonal influenza vaccination on the antibody response produced by natural infection or vaccination is not well understood.
methodsWe compared the profiles of antibody responses of 32 naturally infected subjects and 98 subjects vaccinated with a 2009 influenza A(H1N1) monovalent MF59-adjuvanted vaccine (Focetria, Novartis), with and without a history of seasonal influenza vaccination. Antibodies were measured by hemagglutination inhibition (HI) assay for influenza A(H1N1)pdm09 and by protein microarray (PA) using the HA1 subunit for seven recent and historic H1, H2 and H3 influenza viruses, and three avian influenza viruses. Serum samples for the infection group were taken at the moment of collection of the diagnostic sample, 10 days and 30 days after onset of influenza symptoms. For the vaccination group, samples were drawn at baseline, 3 weeks after the first vaccination and 5 weeks after the second vaccination.
resultsWe showed that subjects with a history of seasonal vaccination generally exhibited higher baseline titers for the various HA1 antigens than subjects without a seasonal vaccination history. Infection and pandemic influenza vaccination responses in persons with a history of seasonal vaccination were skewed towards historic antigens.
conclusionsSeasonal vaccination is of significant influence on the antibody response to subsequent infection and vaccination, and further research is needed to understand the effect of annual vaccination on protective immunity.
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