ArticlePloS one2013
Relationship between carotid intima media thickness and helminth infections on Flores Island, Indonesia.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.
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Who cites it
27 citing papers in PubMed, 1 synthesis or guideline pooled it, 58 citations in OpenAlex.
- Effects of helminths and anthelmintic treatment on cardiometabolic diseases and risk factors: A systematic review.PLoS neglected tropical diseases · 2023Pooled it
- Effect of experimental hookworm infection on insulin resistance in people at risk of type 2 diabetes.Nature communications · 2023Trial
- The Effect of Helminth Infections and Their Treatment on Metabolic Outcomes: Results of a Cluster-Randomized Trial.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2020Trial
- Effect of a short course of iron polymaltose on acquisition of malarial parasitaemia in anaemic Indonesian schoolchildren: a randomized trial.Malaria journal · 2017Trial
- Prevalence and associated factors of intestinal parasitic infections in the school children of Sarlahi, Nepal.Parasite epidemiology and control · 2026Article
- The gut microbiome and metabolome associate with Schistosoma mansoni infection and cardiovascular disease risk in Uganda.Nature communications · 2026Article
- Three common assumptions about inflammation, aging, and health that are probably wrong.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Inhibition Effects ofPathogens (Basel, Switzerland) · 2022Article
- Association between Intestinal Parasite Infections and Proxies for Body Composition: A Scoping Review.Nutrients · 2022Article
- Helminth infection modulates number and function of adipose tissue Tregs in high fat diet-induced obesity.PLoS neglected tropical diseases · 2022Article
- Helminth and Host Crosstalk: New Insight Into Treatment of Obesity and Its Associated Metabolic Syndromes.Frontiers in immunology · 2022Review
- The determinants of lipid profiles in early adolescence in a Ugandan birth cohort.Scientific reports · 2021Article
- Schistosoma haematobium infection is associated with lower serum cholesterol levels and improved lipid profile in overweight/obese individuals.PLoS neglected tropical diseases · 2020Article
- Neglected Agent Eminent Disease: Linking Human Helminthic Infection, Inflammation, and Malignancy.Frontiers in cellular and infection microbiology · 2019Review
- Association between helminth infections and diabetes mellitus in adults from the Lao People's Democratic Republic: a cross-sectional study.Infectious diseases of poverty · 2018Article
- Prediction of the development of metabolic syndrome by the Markov model based on a longitudinal study in Dalian City.BMC public health · 2018Article
- Helminth infection protects against high fat diet-induced obesity via induction of alternatively activated macrophages.Scientific reports · 2018Article
- Praziquantel treatment after Schistosoma japonicum infection maintains hepatic insulin sensitivity and improves glucose metabolism in mice.Parasites & vectors · 2017Article
- Hookworm infection is associated with decreased CD4+ T cell counts in HIV-infected adult Ugandans.PLoS neglected tropical diseases · 2017Article
- Nematodes and human therapeutic trials for inflammatory disease.Parasite immunology · 2017Review
Corrections and comments
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Authors and funding
14 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo examine the association between helminth infections and atherosclerosis.
backgroundChronic helminth infection, which can lead to poor nutritional status and anti-inflammatory response, might protect against the development of atherosclerosis.
methodsA cross-sectional study was performed in Flores, Indonesia, an area highly endemic for soil-transmitted helminths (STH). Stool samples from 675 participants aged 18-80 years were collected and screened for Trichuris trichiura by microscopy and for Ascaris lumbricoides, Necator americanus, Ancylostoma duodenale, and Strongyloides stercoralis by qPCR. We collected data on body mass index (BMI), waist to hip ratio (WHR), blood pressure, fasting blood glucose (FBG), lipid, high sensitive C-reactive protein (hs-CRP), total immunoglobulin-E (TIgE) and Escherichia coli lipopolysaccharide stimulated cytokines (tumor necrosis factor and interleukin-10). In a subset of 301 elderly adults (≥40 years of age) carotid intima media thickness (cIMT) was measured.
resultsParticipants with any STH infection had lower BMI (kg/m2) (mean difference -0.66, 95%CI [-1.26, -0.06]), WHR (-0.01, [-0.02, -0.00]), total cholesterol (mmol/L) (-0.22, [-0.43, -0.01]) and LDL-cholesterol (mmol/L) (-0.20, [-0.39, -0.00]) than uninfected participants. After additional adjustment for BMI the association between helminth infection and total cholesterol (mean difference -0.17, 95%CI [-0.37, 0.03]) as well as LDL-cholesterol (-0.15, [-0.33, 0.04]) was less pronounced. BMI, WHR, and total cholesterol were negatively associated with number species of helminth co-infections. Participants with high TIgE, an indicator of exposure to helminths, had lower FBG, TC, and HDL. The association between TIgE and TC and HDL remained significant after adjustment with BMI. No clear association was found between STH infection or TIgE and mean cIMT.
conclusionsThis cross-sectional study presents evidence that helminth infections were negatively associated with risk factors for cardiovascular disease, an association at least partially mediated by an effect on BMI. The significance of this finding needs to be determined.
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