ArticlePloS one2013
Pediatric invasive pneumococcal disease caused by vaccine serotypes following the introduction of conjugate vaccination in Denmark.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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17 citing papers in PubMed, 32 citations in OpenAlex.
- Incidence of Invasive and Noninvasive Pneumococcal Pneumonia Hospitalizations in People Aged ≥50 Years: Assessing Variability Across Denmark and Spain.The Journal of infectious diseases · 2024Article
- [Meningitis caused by Streptococcus pneumoniae serotype 7a in an infant vaccinated with two doses of 13-valent pneumococcal conjugate vaccine: a case study].The Pan African medical journal · 2019Article
- Article
- The epidemiology of invasive pneumococcal disease in older adults in the post-PCV era. Has there been a herd effect?Epidemiology and infection · 2017Article
- The incidence of invasive pneumococcal serotype 3 disease in the Danish population is not reduced by PCV-13 vaccination.Heliyon · 2016Article
- Article
- Other age groups than children need to be considered as carriers of Streptococcal pneumoniae serotypes.Human vaccines & immunotherapeutics · 2016Article
- Effect of the introduction of pneumococcal conjugate vaccination on invasive pneumococcal disease in The Gambia: a population-based surveillance study.The Lancet. Infectious diseases · 2016Article
- Molecular epidemiology of pneumococcal isolates from children in China.Saudi medical journal · 2016Article
- Pneumococcal serotype evolution in Western Europe.BMC infectious diseases · 2015Review
- Pneumococcal vaccine failure: can it be a primary immunodeficiency?BMJ case reports · 2014Article
- Pneumococcal empyema and complicated pneumonias: global trends in incidence, prevalence, and serotype epidemiology.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2014Review
- Towards the 13-valent pneumococcal conjugate universal vaccination: effectiveness in the transition era between PCV7 and PCV13 in Italy, 2010-2013.Human vaccines & immunotherapeutics · 2014Article
- Changing trends in serotype distribution and antimicrobial susceptibility of Streptococcus pneumoniae causing invasive diseases in Central Thailand, 2009-2012.Human vaccines & immunotherapeutics · 2014Article
- Invasive pneumococcal isolates from Danish infants (0 - 90 Days) during the years 1943 to 2013.PloS one · 2014Article
- Pneumococcal aetiology and serotype distribution in paediatric community-acquired pneumonia.PloS one · 2014Observational
- Serotype-specific changes in invasive pneumococcal disease after pneumococcal conjugate vaccine introduction: a pooled analysis of multiple surveillance sites.PLoS medicine · 2013Article
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Authors and funding
12 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A seven-valent pneumococcal conjugate vaccine (PCV7) was introduced in the Danish childhood immunization program (2+1 schedule) in October 2007, followed by PCV13 starting from April 2010. The nationwide incidence of IPD among children younger than 5 years nearly halved after the introduction of PCV7 in the program, mainly due to a decline in IPD caused by PCV7-serotypes. We report the results from a nationwide population-based cohort study of laboratory confirmed IPD cases in children younger than 5 years during October 1, 2007 to December 31, 2010 and describe the characteristics of children suspected to present with a vaccine failure. The period between April 19 and December 31, 2010 was considered a PCV7/PCV13 transitional period, where both vaccines were offered. We identified 45 episodes of IPD caused by a PCV7 serotype (23% of the total number) and 105 (55%) caused by one of the 6 additional serotypes in PCV13. Ten children had received at least one PCV7 dose before the onset of IPD caused by a PCV7 serotype. Seven children were considered to be incompletely vaccinated before IPD, but only three cases fulfilled the criteria of vaccine failure (caused by serotypes 14, 19F and 23F). One case of vaccine failure was observed in a severely immunosuppressed child following three PCV7 doses, and two cases were observed in immunocompetent children following two infant doses before they were eligible for their booster. None of the IPD cases caused by the additional PCV13 serotypes had been vaccinated by PCV13 and there were therefore no PCV13-vaccine failures in the first 8-months after PCV13 introduction in Denmark.
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