ArticleInfectious diseases in obstetrics and gynecology2013
CD8⁺CXCR5⁺ T cells regulate pathology in the genital tract.
Article in Infectious diseases in obstetrics and gynecology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
9 citing papers in PubMed, 13 citations in OpenAlex.
- Protective anti-chlamydial vaccine regimen-induced CD4+ T cell response mediates early inhibition of pathogenic CD8+ T cell response following genital challenge.Pathogens and disease · 2024Article
- Characterization of Pathogenic CD8Infection and immunity · 2022Article
- Providing a Helping Hand: Metabolic Regulation of T Follicular Helper Cells and Their Association With Disease.Frontiers in immunology · 2022Review
- CXCR5+ CD8 T Cells: Protective or Pathogenic?Frontiers in immunology · 2019Review
- CXCR5 and ICOS expression identifies a CD8 T-cell subset with TBlood advances · 2018Article
- CD8 Follicular T Cells Promote B Cell Antibody Class Switch in Autoimmune Disease.Journal of immunology (Baltimore, Md. : 1950) · 2018Article
- The contribution of Chlamydia-specific CD8⁺ T cells to upper genital tract pathology.Immunology and cell biology · 2016Article
- Glucocorticoid-induced tumour necrosis factor receptor-related protein: a key marker of functional regulatory T cells.Journal of immunology research · 2015Review
- Immunopathogenesis of Chlamydial Infections.Current topics in microbiology and immunologyReview
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
We have identified a CD8⁺CXCR5⁺ T cell that prevents the development of oviduct dilation following C. muridarum genital infection. Phenotypic studies show that CD8⁺CXCR5⁺ cells express markers of T regulatory cells (FoxP3, CD25, and GITR) but do not express a necessary component of cytotoxic cells (perforin). Cxcr5⁻/⁻ mice have significantly lower numbers of CD8⁺ cells and lack the CD8⁺CXCR5⁺ population while the total number of CD4⁺ cells is equivalent between mouse strains. The transfer of CD8⁺ splenocytes from WT mice reduces the oviduct dilation seen in Cxcr5⁻/⁻ mice following C. muridarum infection. Future studies will investigate the mechanism by which this cell type regulates genital tract pathology.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.