ReviewMediators of inflammation2013
Role of mitogen-activated protein kinase pathways in multifactorial adverse cardiac remodeling associated with metabolic syndrome.
Review in Mediators of inflammation, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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Who cites it
20 citing papers in PubMed, 34 citations in OpenAlex.
- Unravelling bovine preadipocyte differentiation and their three-dimensional cultivation for cellular agriculture.NPJ science of food · 2025Article
- Signalling pathways involved in urotensin II induced ventricular myocyte hypertrophy.PloS one · 2025Article
- Sex Differences in Expression of Pro-Inflammatory Markers and miRNAs in a Mouse Model of CVB3 Myocarditis.International journal of molecular sciences · 2024Article
- Insulin-Heart Axis: Bridging Physiology to Insulin Resistance.International journal of molecular sciences · 2024Review
- Cellular interplay between cardiomyocytes and non-myocytes in diabetic cardiomyopathy.Cardiovascular research · 2023Review
- Tissue Engineering Techniques for Induced Pluripotent Stem Cell Derived Three-Dimensional Cardiac Constructs.Tissue engineering. Part B, Reviews · 2022Review
- Neuropeptide Y attenuates cardiac remodeling and deterioration of function following myocardial infarction.Molecular therapy : the journal of the American Society of Gene Therapy · 2022Article
- MicroRNA expression profile and identification of novel microRNA biomarkers for metabolic syndrome.Bioengineered · 2021Article
- Non-'classical' MEKs: A review of MEK3-7 inhibitors.Bioorganic & medicinal chemistry letters · 2020Review
- Isolation and Identification of Bovine Preadipocytes and Screening of MicroRNAs Associated with Adipogenesis.Animals : an open access journal from MDPI · 2020Article
- Role of mineralocorticoid receptor activation in cardiac diastolic dysfunction.Biochimica et biophysica acta. Molecular basis of disease · 2017Review
- Diabetic cardiomyopathy: where we are and where we are going.The Korean journal of internal medicine · 2017Review
- Acute exercise activates p38 MAPK and increases the expression of telomere-protective genes in cardiac muscle.Experimental physiology · 2017Article
- How cardiomyocytes sense pathophysiological stresses for cardiac remodeling.Cellular and molecular life sciences : CMLS · 2017Review
- Insulin resistance and hyperinsulinaemia in diabetic cardiomyopathy.Nature reviews. Endocrinology · 2016Review
- S100A8 and S100A9 Are Associated with Doxorubicin-Induced Cardiotoxicity in the Heart of Diabetic Mice.Frontiers in physiology · 2016Article
- Early Cellular Changes in the Ascending Aorta and Myocardium in a Swine Model of Metabolic Syndrome.PloS one · 2016Article
- A pathway and network review on beta-adrenoceptor signaling and beta blockers in cardiac remodeling.Heart failure reviews · 2014Review
- Toll-like receptor 4 mediates inflammatory cytokine secretion in smooth muscle cells induced by oxidized low-density lipoprotein.PloS one · 2014Article
- MAPKs and signal transduction in the control of gastrointestinal epithelial cell proliferation and differentiation.International journal of molecular sciences · 2013Review
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Metabolic syndrome has been widely associated with an increased risk for acute cardiovascular events. Emerging evidence supports metabolic syndrome as a condition favoring an adverse cardiac remodeling, which might evolve towards heart dysfunction and failure. This pathological remodeling has been described to result from the cardiac adaptive response to clinical mechanical conditions (such as hypertension, dyslipidemia, and hyperglycemia), soluble inflammatory molecules (such as cytokines and chemokines), as well as hormones (such as insulin), characterizing the pathophysiology of metabolic syndrome. Moreover, these cardiac processes (resulting in cardiac hypertrophy and fibrosis) are also associated with the modulation of intracellular signalling pathways within cardiomyocytes. Amongst the different intracellular kinases, mitogen-activated protein kinases (MAPKs) were shown to be involved in heart damage in metabolic syndrome. However, their role remains controversial. In this paper, we will discuss and update evidence on MAPK-mediated mechanisms underlying cardiac adverse remodeling associated with metabolic syndrome.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.