ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2013
Functional impact of dendritic branch-point morphology.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers.
What it found
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Who cites it
55 citing papers in PubMed.
- Loss of Fmr1 causes subnucleus-specific decreases in dendritic complexity in mediodorsal thalamus.Brain structure & function · 2026Article
- Axon collateralization and focal myelin dystrophy alter action potential propagation in multicompartment pyramidal neuron models.PLoS computational biology · 2025Article
- Inhibition of TRPM3 channels in the medial prefrontal cortex mitigates OCD symptoms following traumatic brain injury.Inflammopharmacology · 2025Article
- Exploring the microbiota-gut-brain axis: impact on brain structure and function.Frontiers in neuroanatomy · 2025Review
- A method for quantifying parallel growth between neuronal dendritic branches in vitro.PloS one · 2025Article
- Antibiotics-induced dysbiosis impacts dendritic morphology of adult mouse cortical interneurons.Frontiers in neuroanatomy · 2025Article
- From Brain Models to Robotic Embodied Cognition: How Does Biological Plausibility Inform Neuromorphic Systems?Brain sciences · 2023Review
- Altered dendritic morphology in dorsolateral prefrontal cortex of nonhuman primates prenatally exposed to maternal immune activation.Brain, behavior, and immunity · 2023Article
- Semi-Automated Quantitative Evaluation of Neuron Developmental Morphology In Vitro Using the Change-Point Test.Neuroinformatics · 2023Article
- Impact of Maternal Immune Activation on Nonhuman Primate Prefrontal Cortex Development: Insights for Schizophrenia.Biological psychiatry · 2022Review
- Layer-specific pyramidal neuron properties underlie diverse anterior cingulate cortical motor and limbic networks.Cerebral cortex (New York, N.Y. : 1991) · 2022Article
- Active Dendrites and Local Field Potentials: Biophysical Mechanisms and Computational Explorations.Neuroscience · 2022Review
- Morpho-Electric Properties and Diversity of Oxytocin Neurons in Paraventricular Nucleus of Hypothalamus in Female and Male Mice.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Emergence of synaptic organization and computation in dendrites.Neuroforum · 2022Review
- Ste20-like Kinase Is Critical for Inhibitory Synapse Maintenance and Its Deficiency Confers a Developmental Dendritopathy.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Article
- Modeling Neurotransmission: Computational Tools to Investigate Neurological Disorders.International journal of molecular sciences · 2021Review
- Comprehensive Estimates of Potential Synaptic Connections in Local Circuits of the Rodent Hippocampal Formation by Axonal-Dendritic Overlap.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- The Input-Output Relation of Primary Nociceptive Neurons is Determined by the Morphology of the Peripheral Nociceptive Terminals.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Statistical Laws of Protein Motion in Neuronal Dendritic Trees.Cell reports · 2020Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Cortical pyramidal cells store multiple features of complex synaptic input in individual dendritic branches and independently regulate the coupling between dendritic and somatic spikes. Branch points in apical trees exhibit wide ranges of sizes and shapes, and the large diameter ratio between trunk and oblique dendrites exacerbates impedance mismatch. The morphological diversity of dendritic bifurcations could thus locally tune neuronal excitability and signal integration. However, these aspects have never been investigated. Here, we first quantified the morphological variability of branch points from two-photon images of rat CA1 pyramidal neurons. We then investigated the geometrical features affecting spike initiation, propagation, and timing with a computational model validated by glutamate uncaging experiments. The results suggest that even subtle membrane readjustments at branch points could drastically alter the ability of synaptic input to generate, propagate, and time action potentials.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.