ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2013
Biphasic cholinergic synaptic transmission controls action potential activity in thalamic reticular nucleus neurons.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.
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Who cites it
47 citing papers in PubMed.
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- Targeting disrupted networks in schizophrenia: Can muscarinic drugs make a fundamental difference?Journal of psychopharmacology (Oxford, England) · 2025Review
- Differential Regulation of Prelimbic and Thalamic Transmission to the Basolateral Amygdala by Acetylcholine Receptors.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Synaptic-like axo-axonal transmission from striatal cholinergic interneurons onto dopaminergic fibers.Neuron · 2022Article
- The organization of cholinergic projections in the visual thalamus of the mouse.The Journal of comparative neurology · 2022Article
- Identification of transcriptome alterations in the prefrontal cortex, hippocampus, amygdala and hippocampus of suicide victims.Scientific reports · 2021Article
- Article
- Top-down acetylcholine signaling via olfactory bulb vasopressin cells contributes to social discrimination in rats.Communications biology · 2021Article
- Long-Term Value Memory in the Primate Posterior Thalamus for Fast Automatic Action.Current biology : CB · 2020Article
- TRPM4 Conductances in Thalamic Reticular Nucleus Neurons Generate Persistent Firing during Slow Oscillations.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Oscillating circuitries in the sleeping brain.Nature reviews. Neuroscience · 2019Review
- Cerebral sodium (European radiology · 2019Article
- Postnatal development of cholinergic input to the thalamic reticular nucleus of the mouse.The European journal of neuroscience · 2019Article
- Thalamic inhibitory circuits and network activity development.Brain research · 2019Review
- The Pharmacology of Visual Hallucinations in Synucleinopathies.Frontiers in pharmacology · 2019Review
- Co-transmission of acetylcholine and GABA regulates hippocampal states.Nature communications · 2018Article
- Synaptic Release of Acetylcholine Rapidly Suppresses Cortical Activity by Recruiting Muscarinic Receptors in Layer 4.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
- Stoichiometry of the Heteromeric Nicotinic Receptors of the Renshaw Cell.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
- Fluidic Microactuation of Flexible Electrodes for Neural Recording.Nano letters · 2018Article
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7 authors.
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Abstract
Cholinergic neurons in the basal forebrain and the brainstem form extensive projections to a number of thalamic nuclei. Activation of cholinergic afferents during distinct behavioral states can regulate neuronal firing, transmitter release at glutamatergic and GABAergic synapses, and synchrony in thalamic networks, thereby controlling the flow of sensory information. These effects are thought to be mediated by slow and persistent increases in extracellular ACh levels, resulting in the modulation of populations of thalamic neurons over large temporal and spatial scales. However, the synaptic mechanisms underlying cholinergic signaling in the thalamus are not well understood. Here, we demonstrate highly reliable cholinergic transmission in the mouse thalamic reticular nucleus (TRN), a brain structure essential for sensory processing, arousal, and attention. We find that ACh release evoked by low-frequency stimulation leads to biphasic excitatory-inhibitory (E-I) postsynaptic responses, mediated by the activation of postsynaptic α4β2 nicotinic ACh receptors (nAChRs) and M2 muscarinic ACh receptors (mAChRs), respectively. In addition, ACh can bind to mAChRs expressed near cholinergic release sites, resulting in autoinhibition of release. We show that the activation of postsynaptic nAChRs by transmitter release from only a small number of individual axons is sufficient to trigger action potentials in TRN neurons. Furthermore, short trains of cholinergic synaptic inputs can powerfully entrain ongoing TRN neuronal activity. Our study demonstrates fast and precise synaptic E-I signaling mediated by ACh, suggesting novel computational mechanisms for the cholinergic control of neuronal activity in thalamic circuits.
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