ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2013
Distinct modes of dopamine and GABA release in a dual transmitter neuron.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers.
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Who cites it
57 citing papers in PubMed, 85 citations in OpenAlex.
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- Functional Maturation and Experience-Dependent Plasticity in Adult-Born Olfactory Bulb Dopaminergic Neurons.The European journal of neuroscience · 2025Article
- New Neurons in the Postnatal Olfactory System: Functions in the Healthy and Regenerating Brain.Brain sciences · 2025Review
- Concept transfer of synaptic diversity from biological to artificial neural networks.Nature communications · 2025Article
- Intrinsic and synaptic regulation of axonal excitability in dopaminergic neurons.Frontiers in cellular neuroscience · 2025Review
- Evolutionary innovations in the primate dopaminergic system.Current opinion in genetics & development · 2024Review
- Nanoelectrochemistry reveals how presynaptic neurons regulate vesicle release to sustain synaptic plasticity under repetitive stimuli.Chemical science · 2024Article
- Impaired olfactory performance and anxiety-like behavior in a rat model of multiple sclerosis are associated with enhanced adenosine signaling in the olfactory bulb via AFrontiers in cellular neuroscience · 2024Article
- Beyond anosmia: olfactory dysfunction as a common denominator in neurodegenerative and neurodevelopmental disorders.Frontiers in neuroscience · 2024Review
- Brief sensory deprivation triggers plasticity of dopamine-synthesising enzyme expression in genetically labelled olfactory bulb dopaminergic neurons.The European journal of neuroscience · 2022Article
- Methamphetamine Dysregulation of the Central Nervous System and Peripheral Immunity.The Journal of pharmacology and experimental therapeutics · 2021Review
- Dopamine Transporter Is a Master Regulator of Dopaminergic Neural Network Connectivity.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Spatial and temporal scales of dopamine transmission.Nature reviews. Neuroscience · 2021Review
- Brief Sensory Deprivation Triggers Cell Type-Specific Structural and Functional Plasticity in Olfactory Bulb Neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Unraveling the Role of Dopaminergic and Calretinin Interneurons in the Olfactory Bulb.Frontiers in neural circuits · 2021Review
- Functional Implications of Neurotransmitter Segregation.Frontiers in neural circuits · 2021Review
- Evaluation of electrochemical methods for tonic dopamine detectionTrends in analytical chemistry : TRAC · 2020Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
We now know of a surprising number of cases where single neurons contain multiple neurotransmitters. Neurons that contain a fast-acting neurotransmitter, such as glutamate or GABA, and a modulatory transmitter, such as dopamine, are a particularly interesting case because they presumably serve dual signaling functions. The olfactory bulb contains a large population of GABA- and dopamine-containing neurons that have been implicated in normal olfaction as well as in Parkinson's disease. Yet, they have been classified as nonexocytotic catecholamine neurons because of the apparent lack of vesicular monoamine transporters. Thus, we examined how dopamine is stored and released from tyrosine hydroxylase-positive GFP (TH(+)-GFP) mouse periglomerular neurons in vitro. TH(+) cells expressed both VMAT2 (vesicular monoamine transporter 2) and VGAT (vesicular GABA transporter), consistent with vesicular storage of both dopamine and GABA. Carbon fiber amperometry revealed that release of dopamine was quantal and calcium-dependent, but quantal size was much less than expected for large dense core vesicles, suggesting that release originated from small clear vesicles identified by electron microscopy. A single action potential in a TH(+) neuron evoked a brief GABA-mediated synaptic current, whereas evoked dopamine release was asynchronous, lasting for tens of seconds. Our data suggest that dopamine and GABA serve temporally distinct roles in these dual transmitter neurons.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.