ArticleJournal of lipid research2013
Simulation of triacylglycerol ion profiles: bioinformatics for interpretation of triacylglycerol biosynthesis.
Article in Journal of lipid research, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed.
- Lipid droplets as cell fate determinants in skeletal muscle.Trends in endocrinology and metabolism: TEM · 2025Review
- Article
- The foundations and development of lipidomics.Journal of lipid research · 2022Review
- Overview of Lipidomic Analysis of Triglyceride Molecular Species in Biological Lipid Extracts.Journal of agricultural and food chemistry · 2021Article
- Effect of palmitoleic acid on the differentiation of bovine skeletal muscle satellite cells.Journal of animal science and technology · 2021Article
- Normalization methods for reducing interbatch effect without quality control samples in liquid chromatography-mass spectrometry-based studies.Analytical and bioanalytical chemistry · 2021Article
- Coupling Machine Learning and Lipidomics as a Tool to Investigate Metabolic Dysfunction-Associated Fatty Liver Disease. A General Overview.Biomolecules · 2021Review
- Treatment of human skeletal muscle cells with inhibitors of diacylglycerol acyltransferases 1 and 2 to explore isozyme-specific roles on lipid metabolism.Scientific reports · 2020Article
- Lipidomic analysis reveals significant lipogenesis and accumulation of lipotoxic components in ob/ob mouse organs.Prostaglandins, leukotrienes, and essential fatty acids · 2018Article
- Shared and distinct lipid-lipid interactions in plasma and affected tissues in a diabetic mouse model.Journal of lipid research · 2018Article
- Lipidomics for precision medicine and metabolism: A personal view.Biochimica et biophysica acta. Molecular and cell biology of lipids · 2017Review
- Lipidomics for studying metabolism.Nature reviews. Endocrinology · 2016Review
- Lipidomics: Techniques, Applications, and Outcomes Related to Biomedical Sciences.Trends in biochemical sciences · 2016Review
- Shotgun Lipidomics Approach to Stabilize the Regiospecificity of Monoglycerides Using a Facile Low-Temperature Derivatization Enabling Their Definitive Identification and Quantitation.Analytical chemistry · 2016Article
- MondoA coordinately regulates skeletal myocyte lipid homeostasis and insulin signaling.The Journal of clinical investigation · 2016Article
- CytochromeNPJ aging and mechanisms of disease · 2016Article
- Novel advances in shotgun lipidomics for biology and medicine.Progress in lipid research · 2016Review
- Improved method for quantitative analysis of methylated phosphatidylethanolamine species and its application for analysis of diabetic-mouse liver samples.Analytical and bioanalytical chemistry · 2015Article
- Comprehensive quantification of triacylglycerols in soybean seeds by electrospray ionization mass spectrometry with multiple neutral loss scans.Scientific reports · 2014Article
- Fatty acidomics: global analysis of lipid species containing a carboxyl group with a charge-remote fragmentation-assisted approach.Analytical chemistry · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
Although the synthesis pathways of intracellular triacylglycerol (TAG) species have been well elucidated, assessment of the contribution of an individual pathway to TAG pools in different mammalian organs, particularly under pathophysiological conditions, is difficult, although not impossible. Herein, we developed and validated a novel bioinformatic approach to assess the differential contributions of the known pathways to TAG pools through simulation of TAG ion profiles determined by shotgun lipidomics. This powerful approach was applied to determine such contributions in mouse heart, liver, and skeletal muscle and to examine the changes of these pathways in mouse liver induced after treatment with a high-fat diet. It was clearly demonstrated that assessment of the altered TAG biosynthesis pathways under pathophysiological conditions can be readily achieved through simulation of lipidomics data. Collectively, this new development should greatly facilitate our understanding of the biochemical mechanisms underpinning TAG accumulation at the states of obesity and lipotoxicity.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.