ArticleJournal of immunology (Baltimore, Md. : 1950)2013
Activation of invariant NK T cells in periodontitis lesions.
Article in Journal of immunology (Baltimore, Md. : 1950), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Influence of Natural Killer Cells and Natural Killer T Cells on Periodontal Disease: A Systematic Review of the Current Literature.International journal of molecular sciences · 2020Pooled it
- Loricrin and Cytokeratin Disorganisation in Severe Forms of Periodontitis.International dental journal · 2023Article
- The Epidermal Transcriptome Analysis of a Novel c.639_642dupInternational journal of molecular sciences · 2023Article
- A comprehensive multiparameter flow cytometry panel for immune profiling and functional studies of frozen tissue, bone marrow, and spleen.Journal of immunological methods · 2023Article
- Maintaining homeostatic control of periodontal bone tissue.Periodontology 2000 · 2021Review
- Natural Killer T (NKT) Cells and Periodontitis: Potential Regulatory Role of NKT10 Cells.Mediators of inflammation · 2021Review
- The influence ofCentral-European journal of immunology · 2017Article
- Genome-Wide Analysis of Periodontal and Peri-Implant Cells and Tissues.Methods in molecular biology (Clifton, N.J.) · 2017Article
- Differential Expression and Functional Analysis of High-Throughput -Omics Data Using Open Source Tools.Methods in molecular biology (Clifton, N.J.) · 2017Article
- Mini but mighty: microRNAs in the pathobiology of periodontal disease.Periodontology 2000 · 2015Review
- Odanacatib, A Cathepsin K-Specific Inhibitor, Inhibits Inflammation and Bone Loss Caused by Periodontal Diseases.Journal of periodontology · 2015Article
- Immuno-pathogenesis of Periodontal Disease: Current and Emerging Paradigms.Current oral health reports · 2014Article
- Gingival tissue transcriptomes identify distinct periodontitis phenotypes.Journal of dental research · 2014Article
- Molecular differences between chronic and aggressive periodontitis.Journal of dental research · 2013Article
Corrections and comments
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Authors and funding
11 authors.
Funding
Abstract
Periodontitis is one of the most prevalent human inflammatory diseases. The major clinical phenotypes of this polymicrobial, biofilm-mediated disease are chronic and aggressive periodontitis, the latter being characterized by a rapid course of destruction that is generally attributed to an altered immune-inflammatory response against periodontal pathogens. Still, the biological basis for the pathophysiological distinction of the two disease categories has not been well documented yet. Type I NKT cells are a lymphocyte subset with important roles in regulating immune responses to either tolerance or immunity, including immune responses against bacterial pathogens. In this study, we delineate the mechanisms of NKT cell activation in periodontal infections. We show an infiltration of type I NKT cells in aggressive, but not chronic, periodontitis lesions in vivo. Murine dendritic cells infected with aggressive periodontitis-associated Aggregatibacter actinomycetemcomitans triggered a type I IFN response followed by type I NKT cell activation. In contrast, infection with Porphyromonas gingivalis, a principal pathogen in chronic periodontitis, did not induce NKT cell activation. This difference could be explained by the absence of a type I IFN response to P. gingivalis infection. We found these IFNs to be critical for NKT cell activation. Our study provides a conceivable biological distinction between the two periodontitis subforms and identifies factors required for the activation of the immune system in response to periodontal bacteria.
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