ArticleNeurology2013
Sex differences and hemoglobin levels in relation to stroke outcomes.
Article in Neurology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- Analyzing the effects of anemia on the outcomes of mechanical thrombectomy in ischemic stroke patients: a systematic review and meta-analysis.Annals of medicine and surgery (2012) · 2026Article
- Sex-Difference in Stroke Outcome in Young People in Relation to Haemoglobin Level.Cerebrovascular diseases (Basel, Switzerland) · 2026Article
- Impact of anaemia severity on functional outcome in patients with cerebral venous thrombosis: a DOAC-CVT substudy.European stroke journal · 2026Observational
- Sex-specific hemoglobin thresholds and longitudinal trajectories in intracerebral hemorrhage outcomes: a multicenter cohort study.BMC neurology · 2025Article
- Race explains substantial variance in whole blood thiamine diphosphate concentrations.Nutrition research (New York, N.Y.) · 2024Article
- Hematocrit Predicts Poor Prognosis in Patients with Acute Ischemic Stroke or Transient Ischemic Attack.Brain sciences · 2024Article
- Association between baseline hemoglobin level and early neurological deterioration after intravenous thrombolysis in patients with acute ischemic stroke.Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences · 2024Article
- Biomarkers associated with functional improvement after stroke rehabilitation: a systematic review and meta-analysis of randomized controlled trials.Frontiers in neurology · 2023Review
- Hemoglobin to red cell distribution width ratio as a prognostic marker for ischemic stroke after mechanical thrombectomy.Frontiers in aging neuroscience · 2023Article
- Liver fibrosis-4 score predicts outcome of patients with ischemic stroke undergoing intravenous thrombolysis.Frontiers in neurology · 2023Article
- Relationship Between the Hemoglobin-to-Red Cell Distribution Width Ratio and All-Cause Mortality in Ischemic Stroke Patients with Atrial Fibrillation: An Analysis from the MIMIC-IV Database.Neuropsychiatric disease and treatment · 2022Article
- Anemia Is a Risk Factor for the Development of Ischemic Stroke and Post-Stroke Mortality.Journal of clinical medicine · 2021Article
- Effect of haemoglobin levels on outcome in intravenous thrombolysis-treated stroke patients.European stroke journal · 2020Article
- The Hemoglobin, Albumin, Lymphocyte, and Platelet (HALP) Score Is Associated With Poor Outcome of Acute Ischemic Stroke.Frontiers in neurology · 2020Article
- Sex-specific Associations Between Serum Hemoglobin Levels and the Risk of Cause-specific Death in Korea Using the National Health Insurance Service-National Health Screening Cohort (NHIS HEALS).Journal of preventive medicine and public health = Yebang Uihakhoe chi · 2019Article
- Sex differences in stress and immune responses during confinement in Antarctica.Biology of sex differences · 2019Article
- A Systems Analysis of the Relationships Between Anemia and Ischemic Stroke Rehabilitation Based on RNA-Seq Data.Frontiers in genetics · 2019Article
- Association of anemia and hemoglobin decrease during acute stroke treatment with infarct growth and clinical outcome.PloS one · 2018Article
- Article
- Off-hour effect on 3-month functional outcome after acute ischemic stroke: a prospective multicenter registry.PloS one · 2014Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
objectiveWomen have worse outcomes after stroke compared to men. Since women have lower hemoglobin values, we examined whether hemoglobin levels may associate with worse stroke outcomes in women.
methodsWe retrospectively studied 274 patients enrolled in a prospective multicenter study. We explored the relationship of hemoglobin with clinical outcome at 6 months, as measured by the modified Rankin Scale (mRS). Ordinal logistic regression was used to evaluate the independent effect of hemoglobin on clinical outcome, and to explore the influence of sex on that association.
resultsWomen had a lower mean hemoglobin level (11.7 ± 1.8 g/dL) compared to men (13.3 ± 1.7 g/dL). Low hemoglobin was associated with worse 6-month mRS outcomes in univariate analysis (p < 0.001). Lower hemoglobin remained independently associated with poor outcome after adjustment for comorbid disease, stroke severity, age, and sex. The inclusion of hemoglobin in the model attenuated the independent effect of sex on outcome.
conclusionsSex differences in stroke outcome are linked to lower hemoglobin level, which is more prevalent in women. Further examination of this potentially modifiable predictor is warranted.
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