ReviewAmerican journal of physiology. Regulatory, integrative and comparative physiology2013
Comparative physiology and architecture associated with the mammalian urine concentrating mechanism: role of inner medullary water and urea transport pathways in the rodent medulla.
Review in American journal of physiology. Regulatory, integrative and comparative physiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 49 citations in OpenAlex.
- The Renal Function of the Wild Rodent Cerradomys goytaca Reveals Adaptations in the Mechanisms of Urinary Concentration and Solute Excretion.Journal of experimental zoology. Part A, Ecological and integrative physiology · 2026Article
- Intercalated cell function, kidney innate immunity, and urinary tract infections.Pflugers Archiv : European journal of physiology · 2024Review
- Claudin 19 Is Regulated by Extracellular Osmolality in Rat Kidney Inner Medullary Collecting Duct Cells.International journal of molecular sciences · 2019Article
- Mammalian urine concentration: a review of renal medullary architecture and membrane transporters.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2018Review
- Body mass-specific NaAmerican journal of physiology. Regulatory, integrative and comparative physiology · 2018Article
- Renal vascular pericytes: long overlooked and poorly understood, but clearly important, and what about those regulatory pathways?American journal of physiology. Renal physiology · 2018Article
- Synthesis and Assessment of Peptide Gd-DOTA Conjugates Targeting Extradomain B Fibronectin for Magnetic Resonance Molecular Imaging of Prostate Cancer.Molecular pharmaceutics · 2017Article
- The origins of urinary stone disease: upstream mineral formations initiate downstream Randall's plaque.BJU international · 2017Review
- Alternative channels for urea in the inner medulla of the rat kidney.American journal of physiology. Renal physiology · 2015Article
- Activation of protein kinase Cα increases phosphorylation of the UT-A1 urea transporter at serine 494 in the inner medullary collecting duct.American journal of physiology. Cell physiology · 2015Article
- Architecture of the human renal inner medulla and functional implications.American journal of physiology. Renal physiology · 2015Article
- Urea transporter proteins as targets for small-molecule diuretics.Nature reviews. Nephrology · 2015Review
- Towards Automated Three-Dimensional Tracking of Nephrons through Stacked Histological Image Sets.Computational and mathematical methods in medicine · 2015Article
- Database of osmoregulated proteins in mammalian cells.Physiological reports · 2014Article
- Targeted delivery of solutes and oxygen in the renal medulla: role of microvessel architecture.American journal of physiology. Renal physiology · 2014Review
- Diuresis and reduced urinary osmolality in rats produced by small-molecule UT-A-selective urea transport inhibitors.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2014Article
- Complex vascular bundles, thick ascending limbs, and aquaporins: wringing out the outer medulla.American journal of physiology. Renal physiology · 2014Article
- Transepithelial water and urea permeabilities of isolated perfused Munich-Wistar rat inner medullary thin limbs of Henle's loop.American journal of physiology. Renal physiology · 2014Article
- Small-molecule inhibitors of urea transporters.Sub-cellular biochemistry · 2014Review
- The Concise Guide to PHARMACOLOGY 2013/14: transporters.British journal of pharmacology · 2013Article
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
Comparative studies of renal structure and function have potential to provide insights into the urine-concentrating mechanism of the mammalian kidney. This review focuses on the tubular transport pathways for water and urea that play key roles in fluid and solute movements between various compartments of the rodent renal inner medulla. Information on aquaporin water channel and urea transporter expression has increased our understanding of functional segmentation of medullary thin limbs of Henle's loops, collecting ducts, and vasa recta. A more complete understanding of membrane transporters and medullary architecture has identified new and potentially significant interactions between these structures and the interstitium. These interactions are now being introduced into our concept of how the inner medullary urine-concentrating mechanism works. A variety of regulatory pathways lead directly or indirectly to variable patterns of fluid and solute movements among the interstitial and tissue compartments. Animals with the ability to produce highly concentrated urine, such as desert species, are considered to exemplify tubular structure and function that optimize urine concentration. These species may provide unique insights into the urine-concentrating process.(1)
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.